Leen Wolfs

Leuven, VLG, Belgium

Last Updated: 09/26/2026

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Found 17 publications

Human microglial transitions at the Aβ-tau inflection point associate with divergent pathways to dementia and resilience.

Human microglial transitions at the Aβ-tau inflection point associate with divergent pathways to dementia and resilience.

Journal: Nature medicine
Published: July 11, 2025

The Alzheimer's therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia.

The Alzheimer's therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia.

Journal: Nature neuroscience
Published: July 30, 2024

The MIR-NAT MAPT-AS1 does not regulate Tau expression in human neurons.

The MIR-NAT MAPT-AS1 does not regulate Tau expression in human neurons.

Journal: PloS one
Published: July 25, 2024

The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia xenografted into a mouse model of Alzheimer's disease.

The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia xenografted into a mouse model of Alzheimer's disease.

Journal: Nature communications
Published: July 19, 2024

APOE from astrocytes restores Alzheimer's Aβ-pathology and DAM-like responses in APOE deficient microglia.

APOE from astrocytes restores Alzheimer's Aβ-pathology and DAM-like responses in APOE deficient microglia.

Journal: EMBO molecular medicine
Published: April 24, 2024

Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer's disease.

Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer's disease.

Journal: Molecular neurodegeneration
Published: November 24, 2023

The γ-secretase substrate proteome and its role in cell signaling regulation.

The γ-secretase substrate proteome and its role in cell signaling regulation.

Journal: Molecular cell
Published: February 02, 2023

microRNA-132 regulates gene expression programs involved in microglial homeostasis.

microRNA-132 regulates gene expression programs involved in microglial homeostasis.

Journal: iScience
Published: December 22, 2022

Xenografted human microglia display diverse transcriptomic states in response to Alzheimer's disease-related amyloid-β pathology.

Xenografted human microglia display diverse transcriptomic states in response to Alzheimer's disease-related amyloid-β pathology.

Journal: Nature neuroscience
Published: November 28, 2022

Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer's disease.

Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer's disease.

Journal: Cell reports
Published: May 17, 2022

Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer's disease.

Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer's disease.

Journal: Cell stem cell
Published: March 17, 2021

Stem-cell-derived human microglia transplanted into mouse brain to study human disease.

Stem-cell-derived human microglia transplanted into mouse brain to study human disease.

Journal: Nature protocols
Published: July 15, 2020
Showing 1-12 of 17

Last Updated: 09/26/2026