Lei Ma

Guangzhou Municipal And Guangdong Provincial Key Laboratory Of Molecular Target & Clinical Pharmacology, The NMPA And State Key Laboratory Of Respiratory Disease
Guangzhou, 511436, China

Last Updated: 09/26/2026

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Found 14 publications

A unified cobalt-electrocatalytic platform for enantio- and stereo-selective C-H and C-F functionalization of gem-difluoromethylene allenes.

A unified cobalt-electrocatalytic platform for enantio- and stereo-selective C-H and C-F functionalization of gem-difluoromethylene allenes.

Journal: Chemical science

Published: March 18, 2026

Hexafluoroisopropanol-Mediated Cascade Cyclization for Construction of α‑Amino-γ-spirolactones.

Hexafluoroisopropanol-Mediated Cascade Cyclization for Construction of α‑Amino-γ-spirolactones.

Journal: JACS Au

Published: July 30, 2025

Recent advances and therapeutic applications of PPARγ-targeted ligands based on the inhibition mechanism of Ser273 phosphorylation.

Recent advances and therapeutic applications of PPARγ-targeted ligands based on the inhibition mechanism of Ser273 phosphorylation.

Journal: Metabolism: clinical and experimental

Published: September 30, 2024

Access to N-α-deuterated amino acids and DNA conjugates via Ca(II)-HFIP-mediated reductive deutero-amination of α-oxo-carbonyl compounds.

Access to N-α-deuterated amino acids and DNA conjugates via Ca(II)-HFIP-mediated reductive deutero-amination of α-oxo-carbonyl compounds.

Journal: Nature communications

Published: August 20, 2024

Identification of Novel PPARγ Partial Agonists Based on Virtual Screening Strategy: In Silico and In Vitro Experimental Validation.

Identification of Novel PPARγ Partial Agonists Based on Virtual Screening Strategy: In Silico and In Vitro Experimental Validation.

Journal: Molecules (Basel, Switzerland)

Published: August 09, 2024

Structure-based screening, optimization and biological evaluation of novel chrysin-based derivatives as selective PPARγ modulators for the treatment of T2DM and hepatic steatosis.

Structure-based screening, optimization and biological evaluation of novel chrysin-based derivatives as selective PPARγ modulators for the treatment of T2DM and hepatic steatosis.

Journal: European journal of medicinal chemistry

Published: May 27, 2024

Raloxifene-driven benzothiophene derivatives: Discovery, structural refinement, and biological evaluation as potent PPARγ modulators based on drug repurposing.

Raloxifene-driven benzothiophene derivatives: Discovery, structural refinement, and biological evaluation as potent PPARγ modulators based on drug repurposing.

Journal: European journal of medicinal chemistry

Published: January 18, 2024

Structure-based screening and biological validation of the anti-thrombotic drug-dicoumarol as a novel and potent PPARγ-modulating ligand.

Structure-based screening and biological validation of the anti-thrombotic drug-dicoumarol as a novel and potent PPARγ-modulating ligand.

Journal: Bioorganic chemistry

Published: August 04, 2022

Identification of a novel PPARγ modulator with good anti-diabetic therapeutic index via structure-based screening, optimization and biological validation.

Identification of a novel PPARγ modulator with good anti-diabetic therapeutic index via structure-based screening, optimization and biological validation.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Published: July 04, 2022

Correction to: CHD1L prevents lipopolysaccharide-induced hepatocellular carcinomar cell death by activating hnRNP A2/B1-nmMYLK axis.

Correction to: CHD1L prevents lipopolysaccharide-induced hepatocellular carcinomar cell death by activating hnRNP A2/B1-nmMYLK axis.

Journal: Cell death & disease

Published: March 03, 2022

Application of recombinase polymerase amplification method for rapid detection of infectious laryngotracheitis virus.

Application of recombinase polymerase amplification method for rapid detection of infectious laryngotracheitis virus.

Journal: Molecular and cellular probes

Published: May 21, 2020

Identification and structural insight of an effective PPARγ modulator with improved therapeutic index for anti-diabetic drug discovery.

Identification and structural insight of an effective PPARγ modulator with improved therapeutic index for anti-diabetic drug discovery.

Journal: Chemical science

Published: October 31, 2019

Showing 1-12 of 14

Last Updated: 09/26/2026