Lena Spieth

Hermann Rein Str. 3
Goettingen, NI 37075, Germany

Last Updated: 09/26/2026

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Found 22 publications

Single-cell spatial transcriptomic profiling defines a pathogenic inflammatory niche in chronic active multiple sclerosis lesions.

Single-cell spatial transcriptomic profiling defines a pathogenic inflammatory niche in chronic active multiple sclerosis lesions.

Journal: Immunity

Published: April 16, 2025

Apolipoprotein E aggregation in microglia initiates Alzheimer's disease pathology by seeding β-amyloidosis.

Apolipoprotein E aggregation in microglia initiates Alzheimer's disease pathology by seeding β-amyloidosis.

Journal: Immunity

Published: December 05, 2024

Remember oligodendrocytes: Uncovering their overlooked role in Alzheimer's disease.

Remember oligodendrocytes: Uncovering their overlooked role in Alzheimer's disease.

Journal: PLoS biology

Published: September 12, 2024

TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism.

TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism.

Journal: Nature communications

Published: September 08, 2024

In vivo CRISPR screen reveals regulation of macrophage states in neuroinflammation.

In vivo CRISPR screen reveals regulation of macrophage states in neuroinflammation.

Journal: Nature neuroscience

Published: August 01, 2024

Parental origin of transgene modulates amyloid-β plaque burden in the 5xFAD mouse model of Alzheimer's disease.

Parental origin of transgene modulates amyloid-β plaque burden in the 5xFAD mouse model of Alzheimer's disease.

Journal: Neuron

Published: July 09, 2024

Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration.

Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration.

Journal: Science translational medicine

Published: June 05, 2024

Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer's disease model mice.

Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer's disease model mice.

Journal: Nature neuroscience

Published: September 28, 2023

T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis.

T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis.

Journal: Nature neuroscience

Published: August 31, 2023

Apolipoprotein E aggregation in microglia initiates Alzheimer's disease pathology by seeding β-amyloidosis.

Apolipoprotein E aggregation in microglia initiates Alzheimer's disease pathology by seeding β-amyloidosis.

Journal: Immunity

Published: June 08, 2023

Ketogenic diet uncovers differential metabolic plasticity of brain cells.

Ketogenic diet uncovers differential metabolic plasticity of brain cells.

Journal: Science advances

Published: September 16, 2022

Anesthesia triggers drug delivery to experimental glioma in mice by hijacking caveolar transport.

Anesthesia triggers drug delivery to experimental glioma in mice by hijacking caveolar transport.

Journal: Neuro-oncology advances

Published: October 14, 2021

Showing 1-12 of 22

Last Updated: 09/26/2026