Lennart Brewitz

12 Mansfield Road
Oxford, ENG OX13TA, United Kingdom

Last Updated: 09/26/2026

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Found 51 publications

Cephalosporins are potent SARS-CoV-2 main protease inhibitors.

Cephalosporins are potent SARS-CoV-2 main protease inhibitors.

Journal: European journal of medicinal chemistry

Published: March 30, 2026

Substrate-Selective Inhibition of the SARS-CoV-2 Papain-Like Protease: Inhibition of Hydrolysis of Human Over Viral Substrates.

Substrate-Selective Inhibition of the SARS-CoV-2 Papain-Like Protease: Inhibition of Hydrolysis of Human Over Viral Substrates.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany)

Published: January 15, 2026

Structural and Functional Validation of Pseudomonas Savastanoi Ethylene Forming Enzymes Reveals Flexibility in 2-Oxoglutarate Binding Mode and Conformation.

Structural and Functional Validation of Pseudomonas Savastanoi Ethylene Forming Enzymes Reveals Flexibility in 2-Oxoglutarate Binding Mode and Conformation.

Journal: Chembiochem : a European journal of chemical biology

Published: September 16, 2025

C6-Alkoxy substituted penicillins are potent non-covalently binding inhibitors of the SARS-CoV-2 main protease.

C6-Alkoxy substituted penicillins are potent non-covalently binding inhibitors of the SARS-CoV-2 main protease.

Journal: RSC medicinal chemistry

Published: September 07, 2025

Structural basis of the promiscuity of the unusual Fe(II) and 2-oxoglutarate dependent human aspartate/asparagine-β-hydroxylase.

Structural basis of the promiscuity of the unusual Fe(II) and 2-oxoglutarate dependent human aspartate/asparagine-β-hydroxylase.

Journal: Nature communications

Published: August 30, 2025

Profiling Inhibitor Scaffolds for the Cancer Target Jumonji-C Domain-Containing Protein 6.

Profiling Inhibitor Scaffolds for the Cancer Target Jumonji-C Domain-Containing Protein 6.

Journal: ChemMedChem

Published: August 07, 2025

Structural and functional consequences of aspartate/asparagine-β-hydroxylase variants causing Traboulsi syndrome.

Structural and functional consequences of aspartate/asparagine-β-hydroxylase variants causing Traboulsi syndrome.

Journal: The Journal of biological chemistry

Published: June 19, 2025

Derivatives of the Clinically Used HIF Prolyl Hydroxylase Inhibitor Desidustat Are Efficient Inhibitors of Human γ-Butyrobetaine Hydroxylase.

Derivatives of the Clinically Used HIF Prolyl Hydroxylase Inhibitor Desidustat Are Efficient Inhibitors of Human γ-Butyrobetaine Hydroxylase.

Journal: Journal of medicinal chemistry

Published: April 23, 2025

RaPID discovery of cell-permeable helical peptide inhibitors con-taining cyclic β-amino acids against SARS-CoV-2 main protease.

RaPID discovery of cell-permeable helical peptide inhibitors con-taining cyclic β-amino acids against SARS-CoV-2 main protease.

Journal: RSC chemical biology

Published: February 02, 2025

Biochemical investigations using mass spectrometry to monitor JMJD6-catalysed hydroxylation of multi-lysine containing bromodomain-derived substrates.

Biochemical investigations using mass spectrometry to monitor JMJD6-catalysed hydroxylation of multi-lysine containing bromodomain-derived substrates.

Journal: RSC chemical biology

Published: December 15, 2024

Silaproline-bearing nirmatrelvir derivatives are potent inhibitors of the SARS-CoV-2 main protease highlighting the value of silicon-derivatives in structure-activity-relationship studies.

Silaproline-bearing nirmatrelvir derivatives are potent inhibitors of the SARS-CoV-2 main protease highlighting the value of silicon-derivatives in structure-activity-relationship studies.

Journal: European journal of medicinal chemistry

Published: December 12, 2024

Methods for production and assaying catalysis of isolated recombinant human aspartate/asparagine-β-hydroxylase.

Methods for production and assaying catalysis of isolated recombinant human aspartate/asparagine-β-hydroxylase.

Journal: Methods in enzymology

Published: September 20, 2024

Showing 1-12 of 51

Last Updated: 09/26/2026