Leonard W. Seymour

Roosevelt Drive
Oxford, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 66 publications

Hypoxia increases the activity of oncolytic adenoviruses through HIF-2α-stimulated E1A expression.

Hypoxia increases the activity of oncolytic adenoviruses through HIF-2α-stimulated E1A expression.

Journal: Signal transduction and targeted therapy

Published: November 12, 2025

T cell engagers: expanding horizons in oncology and beyond.

T cell engagers: expanding horizons in oncology and beyond.

Journal: British journal of cancer

Published: January 28, 2025

Targeting NKG2D ligands in glioblastoma with a bispecific T-cell engager is augmented with conventional therapy and enhances oncolytic virotherapy of glioma stem-like cells.

Targeting NKG2D ligands in glioblastoma with a bispecific T-cell engager is augmented with conventional therapy and enhances oncolytic virotherapy of glioma stem-like cells.

Journal: Journal for immunotherapy of cancer

Published: April 11, 2024

The implications of oncolytic viruses targeting fibroblasts in enhancing the antitumoural immune response.

The implications of oncolytic viruses targeting fibroblasts in enhancing the antitumoural immune response.

Journal: Heliyon

Published: February 21, 2024

AAV production in stable packaging cells requires expression of adenovirus 22/33K protein to allow episomal amplification of integrated rep/cap genes.

AAV production in stable packaging cells requires expression of adenovirus 22/33K protein to allow episomal amplification of integrated rep/cap genes.

Journal: Scientific reports

Published: September 14, 2023

Oncolytic viruses and antibodies: are they more successful when delivered separately or when engineered as a single agent?

Oncolytic viruses and antibodies: are they more successful when delivered separately or when engineered as a single agent?

Journal: Journal for immunotherapy of cancer

Published: June 25, 2023

Optogenetically Engineered Neurons Differentiated from Human SH-SY5Y Cells Survived and Expressed ChR2 in 3D Hydrogel.

Optogenetically Engineered Neurons Differentiated from Human SH-SY5Y Cells Survived and Expressed ChR2 in 3D Hydrogel.

Journal: Biomedicines

Published: May 17, 2022

Self-attenuating adenovirus enables production of recombinant adeno-associated virus for high manufacturing yield without contamination.

Self-attenuating adenovirus enables production of recombinant adeno-associated virus for high manufacturing yield without contamination.

Journal: Nature communications

Published: July 02, 2021

Deregulation of HLA-I in cancer and its central importance for immunotherapy.

Deregulation of HLA-I in cancer and its central importance for immunotherapy.

Journal: Journal for immunotherapy of cancer

Published: June 21, 2021

Interfaces between cellular responses to DNA damage and cancer immunotherapy.

Interfaces between cellular responses to DNA damage and cancer immunotherapy.

Journal: Genes & development

Published: April 23, 2021

Oncolytic herpesvirus expressing PD-L1 BiTE for cancer therapy: exploiting tumor immune suppression as an opportunity for targeted immunotherapy.

Oncolytic herpesvirus expressing PD-L1 BiTE for cancer therapy: exploiting tumor immune suppression as an opportunity for targeted immunotherapy.

Journal: Journal for immunotherapy of cancer

Published: March 10, 2021

Tackling HLA Deficiencies Head on with Oncolytic Viruses.

Tackling HLA Deficiencies Head on with Oncolytic Viruses.

Journal: Cancers

Published: December 12, 2020

Showing 1-12 of 66

Last Updated: 09/26/2026