Leonardo Sorci

Ancona, Italy

Last Updated: 09/26/2026

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Found 27 publications

NAMPT and NNMT released via extracellular vesicles and as soluble mediators are distinguished traits of BRAF inhibitor resistance of melanoma cells impacting on the tumor microenvironment.

NAMPT and NNMT released via extracellular vesicles and as soluble mediators are distinguished traits of BRAF inhibitor resistance of melanoma cells impacting on the tumor microenvironment.

Journal: Cell communication and signaling : CCS

Published: April 18, 2025

FL30: an epidermal growth factor kinase inhibitor overcoming T790M and C797S mutations through unique conformational modulation mechanism.

FL30: an epidermal growth factor kinase inhibitor overcoming T790M and C797S mutations through unique conformational modulation mechanism.

Journal: International journal of biological macromolecules

Published: March 26, 2025

Probing conformational dynamics of EGFR mutants via SEIRA spectroscopy: potential implications for tyrosine kinase inhibitor design.

Probing conformational dynamics of EGFR mutants via SEIRA spectroscopy: potential implications for tyrosine kinase inhibitor design.

Journal: Physical chemistry chemical physics : PCCP

Published: August 23, 2024

Periplasmic binding proteins Bug69 and Bug27 from Bordetella pertussis are in vitro high-affinity quinolinate binders with a potential role in NAD biosynthesis.

Periplasmic binding proteins Bug69 and Bug27 from Bordetella pertussis are in vitro high-affinity quinolinate binders with a potential role in NAD biosynthesis.

Journal: FEBS open bio

Published: May 29, 2024

Synthesis, Biological, and Computational Evaluations of Conformationally Restricted NAD-Mimics as Discriminant Inhibitors of Human NMN-Adenylyltransferase Isozymes.

Synthesis, Biological, and Computational Evaluations of Conformationally Restricted NAD-Mimics as Discriminant Inhibitors of Human NMN-Adenylyltransferase Isozymes.

Journal: Pharmaceuticals (Basel, Switzerland)

Published: May 07, 2024

Properly Substituted Benzimidazoles as a New Promising Class of Nicotinate Phosphoribosyltransferase (NAPRT) Modulators.

Properly Substituted Benzimidazoles as a New Promising Class of Nicotinate Phosphoribosyltransferase (NAPRT) Modulators.

Journal: Pharmaceuticals (Basel, Switzerland)

Published: December 21, 2022

A Versatile Continuous Fluorometric Enzymatic Assay for Targeting Nicotinate Phosphoribosyltransferase.

A Versatile Continuous Fluorometric Enzymatic Assay for Targeting Nicotinate Phosphoribosyltransferase.

Journal: Molecules (Basel, Switzerland)

Published: December 15, 2022

Mechanistic insight toward EGFR activation induced by ATP: role of mutations and water in ATP binding patterns.

Mechanistic insight toward EGFR activation induced by ATP: role of mutations and water in ATP binding patterns.

Journal: Journal of biomolecular structure & dynamics

Published: August 15, 2022

Molecular insights into the interaction between human nicotinamide phosphoribosyltransferase and Toll-like receptor 4.

Molecular insights into the interaction between human nicotinamide phosphoribosyltransferase and Toll-like receptor 4.

Journal: The Journal of biological chemistry

Published: September 10, 2021

The Prospective Synergy of Antitubercular Drugs With NAD Biosynthesis Inhibitors.

The Prospective Synergy of Antitubercular Drugs With NAD Biosynthesis Inhibitors.

Journal: Frontiers in microbiology

Published: November 28, 2020

Enzymology of extracellular NAD metabolism.

Enzymology of extracellular NAD metabolism.

Journal: Cellular and molecular life sciences : CMLS

Published: September 15, 2020

Inhibition of the NAD salvage pathway in schistosomes impairs metabolism, reproduction, and parasite survival.

Inhibition of the NAD salvage pathway in schistosomes impairs metabolism, reproduction, and parasite survival.

Journal: PLoS pathogens

Published: January 04, 2020

Showing 1-12 of 27

Last Updated: 09/26/2026