Leonie Smeenk

Utrecht, UT, Netherlands

Last Updated: 09/26/2026

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Found 12 publications

MECOM is a master repressor of myeloid differentiation through dose control of CEBPA in acute myeloid leukemia.

MECOM is a master repressor of myeloid differentiation through dose control of CEBPA in acute myeloid leukemia.

Journal: Blood
Published: February 21, 2025

Enhancer Hijacking Discovery in Acute Myeloid Leukemia by Pyjacker Identifies MNX1 Activation via Deletion 7q.

Enhancer Hijacking Discovery in Acute Myeloid Leukemia by Pyjacker Identifies MNX1 Activation via Deletion 7q.

Journal: Blood cancer discovery
Published: October 03, 2024

Oncogene EVI1 drives acute myeloid leukemia via a targetable interaction with CTBP2.

Oncogene EVI1 drives acute myeloid leukemia via a targetable interaction with CTBP2.

Journal: Science advances
Published: May 15, 2024

EVI1 drives leukemogenesis through aberrant ERG activation.

EVI1 drives leukemogenesis through aberrant ERG activation.

Journal: Blood
Published: April 06, 2022

Induced cell-autonomous neutropenia systemically perturbs hematopoiesis in Cebpa enhancer-null mice.

Induced cell-autonomous neutropenia systemically perturbs hematopoiesis in Cebpa enhancer-null mice.

Journal: Blood advances
Published: July 30, 2021

The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops.

The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops.

Journal: Nature communications
Published: June 10, 2021

Selective Requirement of MYB for Oncogenic Hyperactivation of a Translocated Enhancer in Leukemia.

Selective Requirement of MYB for Oncogenic Hyperactivation of a Translocated Enhancer in Leukemia.

Journal: Cancer discovery
Published: December 15, 2020

Derepression of retroelements in acute myeloid leukemia with 3q aberrations.

Derepression of retroelements in acute myeloid leukemia with 3q aberrations.

Journal: Haematologica
Published: December 09, 2020

Atypical 3q26/MECOM rearrangements genocopy inv(3)/t(3;3) in acute myeloid leukemia.

Atypical 3q26/MECOM rearrangements genocopy inv(3)/t(3;3) in acute myeloid leukemia.

Journal: Blood
Published: October 11, 2019

Molecular role of the PAX5-ETV6 oncoprotein in promoting B-cell acute lymphoblastic leukemia.

Molecular role of the PAX5-ETV6 oncoprotein in promoting B-cell acute lymphoblastic leukemia.

Journal: The EMBO journal
Published: August 14, 2016

5-Lipoxygenase is a direct p53 target gene in humans.

5-Lipoxygenase is a direct p53 target gene in humans.

Journal: Biochimica et biophysica acta
Published: March 02, 2015

The B-cell identity factor Pax5 regulates distinct transcriptional programmes in early and late B lymphopoiesis.

The B-cell identity factor Pax5 regulates distinct transcriptional programmes in early and late B lymphopoiesis.

Journal: The EMBO journal
Published: December 11, 2011
Showing 1-12 of 12

Last Updated: 09/26/2026