Leslie A. Mitchell

Pediatrics
805 Washington Blvd S Ste 100
Laurel, MD 20707

Last Updated: 09/26/2026

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Found 43 publications

Human Genome REWRITE for Off-the-Shelf Stem Cells Reveals an "Epigenetic Ghost".

Human Genome REWRITE for Off-the-Shelf Stem Cells Reveals an "Epigenetic Ghost".

Journal: bioRxiv : the preprint server for biology
Published: September 26, 2025

Construction and iterative redesign of synXVI a 903 kb synthetic Saccharomyces cerevisiae chromosome.

Construction and iterative redesign of synXVI a 903 kb synthetic Saccharomyces cerevisiae chromosome.

Journal: Nature communications
Published: June 13, 2024

The de novo design and synthesis of yeast chromosome XIII facilitates investigations on aging.

The de novo design and synthesis of yeast chromosome XIII facilitates investigations on aging.

Journal: Nature communications
Published: March 19, 2024

Establishing chromosomal design-build-test-learn through a synthetic chromosome and its combinatorial reconfiguration.

Establishing chromosomal design-build-test-learn through a synthetic chromosome and its combinatorial reconfiguration.

Journal: Cell genomics
Published: March 27, 2023

Consequences of a telomerase-related fitness defect and chromosome substitution technology in yeast synIX strains.

Consequences of a telomerase-related fitness defect and chromosome substitution technology in yeast synIX strains.

Journal: Cell genomics
Published: October 26, 2022

Synthetic chromosome fusion: Effects on mitotic and meiotic genome structure and function.

Synthetic chromosome fusion: Effects on mitotic and meiotic genome structure and function.

Journal: Cell genomics
Published: October 24, 2022

Dissecting aneuploidy phenotypes by constructing Sc2.0 chromosome VII and SCRaMbLEing synthetic disomic yeast.

Dissecting aneuploidy phenotypes by constructing Sc2.0 chromosome VII and SCRaMbLEing synthetic disomic yeast.

Journal: Cell genomics
Published: October 21, 2022

Synthetic yeast chromosome XI design provides a testbed for the study of extrachromosomal circular DNA dynamics.

Synthetic yeast chromosome XI design provides a testbed for the study of extrachromosomal circular DNA dynamics.

Journal: Cell genomics
Published: October 11, 2022

Super-enhancers include classical enhancers and facilitators to fully activate gene expression.

Super-enhancers include classical enhancers and facilitators to fully activate gene expression.

Journal: Cell
Published: August 08, 2022

Parallel laboratory evolution and rational debugging reveal genomic plasticity to S. cerevisiae synthetic chromosome XIV defects.

Parallel laboratory evolution and rational debugging reveal genomic plasticity to S. cerevisiae synthetic chromosome XIV defects.

Journal: Cell genomics
Published: August 04, 2022

Manipulating the 3D organization of the largest synthetic yeast chromosome.

Manipulating the 3D organization of the largest synthetic yeast chromosome.

Journal: Molecular cell
Published: May 25, 2022

Debugging and consolidating multiple synthetic chromosomes reveals combinatorial genetic interactions.

Debugging and consolidating multiple synthetic chromosomes reveals combinatorial genetic interactions.

Journal: Cell
Published: May 05, 2022
Showing 1-12 of 43

Last Updated: 09/26/2026