Lianru Chen

Guangzhou 510006, PR China
Puerto Rico

Last Updated: 09/26/2026

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Found 10 publications

Discovery of Highly Potent and Orally Available CCNK Molecular Glue Degraders as Broad-Spectrum Antitumor Agents.

Discovery of Highly Potent and Orally Available CCNK Molecular Glue Degraders as Broad-Spectrum Antitumor Agents.

Journal: Journal of medicinal chemistry

Published: October 30, 2025

Discovery of the First-In-Class HSD17B13/PPAR Multitarget Modulators for the Treatment of Metabolic Dysfunction-Associated Steatohepatitis.

Discovery of the First-In-Class HSD17B13/PPAR Multitarget Modulators for the Treatment of Metabolic Dysfunction-Associated Steatohepatitis.

Journal: Journal of medicinal chemistry

Published: October 15, 2025

Discovery of Highly Potent, Selective, and Liver-Targeting HSD17B13 Inhibitor with Robust In Vivo Anti-MASH Activity.

Discovery of Highly Potent, Selective, and Liver-Targeting HSD17B13 Inhibitor with Robust In Vivo Anti-MASH Activity.

Journal: Journal of medicinal chemistry

Published: May 19, 2025

Design, synthesis, and biological evaluation of novel highly selective non-carboxylic acid FABP1 inhibitors.

Design, synthesis, and biological evaluation of novel highly selective non-carboxylic acid FABP1 inhibitors.

Journal: European journal of medicinal chemistry

Published: May 01, 2024

Design, synthesis, and biological evaluation of first-in-class FABP1 inhibitors for the treatment of NASH.

Design, synthesis, and biological evaluation of first-in-class FABP1 inhibitors for the treatment of NASH.

Journal: European journal of medicinal chemistry

Published: November 06, 2023

Design, synthesis, and biological evaluation of deuterated indolepropionic acid derivatives as novel long-acting pan PPARα/γ/δ agonists.

Design, synthesis, and biological evaluation of deuterated indolepropionic acid derivatives as novel long-acting pan PPARα/γ/δ agonists.

Journal: Bioorganic & medicinal chemistry

Published: August 18, 2023

Discovery of novel carboxylesterase 2 inhibitors for the treatment of delayed diarrhea and ulcerative colitis.

Discovery of novel carboxylesterase 2 inhibitors for the treatment of delayed diarrhea and ulcerative colitis.

Journal: Biochemical pharmacology

Published: June 24, 2023

Design, synthesis, and biological studies of novel sulfonamide derivatives as farnesoid X receptor agonists.

Design, synthesis, and biological studies of novel sulfonamide derivatives as farnesoid X receptor agonists.

Journal: European journal of medicinal chemistry

Published: March 21, 2023

Design, synthesis, and biological evaluation studies of novel carboxylesterase 2 inhibitors for the treatment of irinotecan-induced delayed diarrhea.

Design, synthesis, and biological evaluation studies of novel carboxylesterase 2 inhibitors for the treatment of irinotecan-induced delayed diarrhea.

Journal: Bioorganic chemistry

Published: February 16, 2023

Design, synthesis, and biological evaluation of novel dual FFA1 and PPARδ agonists possessing phenoxyacetic acid scaffold.

Design, synthesis, and biological evaluation of novel dual FFA1 and PPARδ agonists possessing phenoxyacetic acid scaffold.

Journal: Bioorganic & medicinal chemistry

Published: October 14, 2021

Showing 1-10 of 10

Last Updated: 09/26/2026