Lieve Lammens

Mechelen-bovelingen, VLG, Belgium

Last Updated: 09/26/2026

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Found 15 publications

Quantitative systems toxicology: modelling to mechanistically understand and predict drug safety.

Quantitative systems toxicology: modelling to mechanistically understand and predict drug safety.

Journal: Nature reviews. Drug discovery

Published: September 17, 2025

Spiro-Azetidine Oxindoles as Long-Acting Injectables for Pre-Exposure Prophylaxis against Respiratory Syncytial Virus Infections.

Spiro-Azetidine Oxindoles as Long-Acting Injectables for Pre-Exposure Prophylaxis against Respiratory Syncytial Virus Infections.

Journal: Journal of medicinal chemistry

Published: June 27, 2024

A dynamic model of the intestinal epithelium integrates multiple sources of preclinical data and enables clinical translation of drug-induced toxicity.

A dynamic model of the intestinal epithelium integrates multiple sources of preclinical data and enables clinical translation of drug-induced toxicity.

Journal: CPT: pharmacometrics & systems pharmacology

Published: February 07, 2023

Safety, Tolerability, and Pharmacokinetics of JNJ-1802, a Pan-serotype Dengue Direct Antiviral Small Molecule, in a Phase 1, Double-Blind, Randomized, Dose-Escalation Study in Healthy Volunteers.

Safety, Tolerability, and Pharmacokinetics of JNJ-1802, a Pan-serotype Dengue Direct Antiviral Small Molecule, in a Phase 1, Double-Blind, Randomized, Dose-Escalation Study in Healthy Volunteers.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Published: January 12, 2023

Homeostasis, injury, and recovery dynamics at multiple scales in a self-organizing mouse intestinal crypt.

Homeostasis, injury, and recovery dynamics at multiple scales in a self-organizing mouse intestinal crypt.

Journal: eLife

Published: December 09, 2022

Mouse organoids as an in vitro tool to study the in vivo intestinal response to cytotoxicants.

Mouse organoids as an in vitro tool to study the in vivo intestinal response to cytotoxicants.

Journal: Archives of toxicology

Published: July 18, 2022

JNJ-67569762, A 2-Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical Candidate.

JNJ-67569762, A 2-Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical Candidate.

Journal: Journal of medicinal chemistry

Published: September 23, 2021

Preclinical toxicity and pharmacokinetics of a new orally bioavailable flubendazole formulation and the impact for clinical trials and risk/benefit to patients.

Preclinical toxicity and pharmacokinetics of a new orally bioavailable flubendazole formulation and the impact for clinical trials and risk/benefit to patients.

Journal: PLoS neglected tropical diseases

Published: June 21, 2018

Translational safety biomarkers of colonic barrier integrity in the rat.

Translational safety biomarkers of colonic barrier integrity in the rat.

Journal: Journal of applied toxicology : JAT

Published: March 05, 2018

Legacy data sharing to improve drug safety assessment: the eTOX project.

Legacy data sharing to improve drug safety assessment: the eTOX project.

Journal: Nature reviews. Drug discovery

Published: October 14, 2017

Bilateral Symmetrical Idiopathic Necrotizing Encephalopathy: A New Syndrome in Sprague-Dawley Rats.

Bilateral Symmetrical Idiopathic Necrotizing Encephalopathy: A New Syndrome in Sprague-Dawley Rats.

Journal: Toxicologic pathology

Published: October 30, 2015

Juvenile animal testing of hydroxypropyl-β-cyclodextrin in support of pediatric drug development.

Juvenile animal testing of hydroxypropyl-β-cyclodextrin in support of pediatric drug development.

Journal: Reproductive toxicology (Elmsford, N.Y.)

Published: March 26, 2015

Showing 1-12 of 15

Last Updated: 09/26/2026