Lilan Xin

Wuhan, 430071, China

Last Updated: 09/26/2026

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Found 23 publications

Discovery of Effective Dual PROTAC Degraders with Synergistic Antitumor Activity for Overcoming Tamoxifen-Resistant Breast Cancer.

Discovery of Effective Dual PROTAC Degraders with Synergistic Antitumor Activity for Overcoming Tamoxifen-Resistant Breast Cancer.

Journal: Journal of medicinal chemistry

Published: July 07, 2026

A novel ERα-targeted hydrophobic tag degrader, overcomes tamoxifen resistance via unfolded protein response-induced apoptosis and homologous recombination repair inhibition in breast cancer.

A novel ERα-targeted hydrophobic tag degrader, overcomes tamoxifen resistance via unfolded protein response-induced apoptosis and homologous recombination repair inhibition in breast cancer.

Journal: Bioorganic chemistry

Published: March 03, 2026

A Novel Dual-Targeting PROTAC Overcomes Endocrine Resistance by Engaging Orthosteric and Allosteric Sites of Estrogen Receptor α.

A Novel Dual-Targeting PROTAC Overcomes Endocrine Resistance by Engaging Orthosteric and Allosteric Sites of Estrogen Receptor α.

Journal: Journal of medicinal chemistry

Published: February 15, 2026

Hydrophobic Tag Degraders Overcome Endocrine-Resistant Breast Cancer by Recruiting HSP27-Mediated E3 Ligase Complex for ERα Proteasomal Degradation.

Hydrophobic Tag Degraders Overcome Endocrine-Resistant Breast Cancer by Recruiting HSP27-Mediated E3 Ligase Complex for ERα Proteasomal Degradation.

Journal: Angewandte Chemie (International ed. in English)

Published: November 21, 2025

A distinct zearalenone detoxification strategy mediated by cytochrome P450.

A distinct zearalenone detoxification strategy mediated by cytochrome P450.

Journal: Food chemistry

Published: November 12, 2025

Hydrophobic tagging: A promising paradigm for targeted protein degradation.

Hydrophobic tagging: A promising paradigm for targeted protein degradation.

Journal: Cell insight

Published: September 28, 2025

Discovery of ERα-targeting PROTACs with intrinsic fluorescence for precision theranostics of breast cancer.

Discovery of ERα-targeting PROTACs with intrinsic fluorescence for precision theranostics of breast cancer.

Journal: RSC medicinal chemistry

Published: April 02, 2025

Pegylated NIR Fluorophore-Conjugated OBHSA Prodrug for ERα-Targeted Theranostics with Enhanced Imaging and Long-Term Retention.

Pegylated NIR Fluorophore-Conjugated OBHSA Prodrug for ERα-Targeted Theranostics with Enhanced Imaging and Long-Term Retention.

Journal: Molecules (Basel, Switzerland)

Published: November 07, 2024

Mechano-oncogenic cytoskeletal remodeling drives leukemic transformation with mitochondrial vesicle-mediated STING activation.

Mechano-oncogenic cytoskeletal remodeling drives leukemic transformation with mitochondrial vesicle-mediated STING activation.

Journal: Cell stem cell

Published: September 16, 2024

Corrigendum to "Structure-guided identification of novel dual-targeting estrogen receptor α degraders with aromatase inhibitory activity for the treatment of endocrine-resistant breast cancer" [Eur. J. Med. Chem. 253 (2023) 115328].

Corrigendum to "Structure-guided identification of novel dual-targeting estrogen receptor α degraders with aromatase inhibitory activity for the treatment of endocrine-resistant breast cancer" [Eur. J. Med. Chem. 253 (2023) 115328].

Journal: European journal of medicinal chemistry

Published: July 27, 2024

Discovery of Novel ERα and Aromatase Dual-Targeting PROTAC Degraders to Overcome Endocrine-Resistant Breast Cancer.

Discovery of Novel ERα and Aromatase Dual-Targeting PROTAC Degraders to Overcome Endocrine-Resistant Breast Cancer.

Journal: Journal of medicinal chemistry

Published: May 29, 2024

Novel Acyl Thiourea-Based Hydrophobic Tagging Degraders Exert Potent Anti-Influenza Activity through Two Distinct Endonuclease Polymerase Acidic-Targeted Degradation Pathways.

Novel Acyl Thiourea-Based Hydrophobic Tagging Degraders Exert Potent Anti-Influenza Activity through Two Distinct Endonuclease Polymerase Acidic-Targeted Degradation Pathways.

Journal: Journal of medicinal chemistry

Published: May 22, 2024

Showing 1-12 of 23

Last Updated: 09/26/2026