Lin Sun

Key Laboratory Of Chemical Biology, 44 West Culture Road, 250012, PR China
Jinan, Puerto Rico

Last Updated: 09/26/2026

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Found 19 publications

Design, synthesis and structure-activity relationships of novel HIV capsid inhibitors with potent antiviral activities.

Design, synthesis and structure-activity relationships of novel HIV capsid inhibitors with potent antiviral activities.

Journal: European journal of medicinal chemistry

Published: March 28, 2025

Discovery of 4-Quinazolinone-Containing Phenylalanine Derivatives as Potent, Resistant-Tolerant HIV Capsid Inhibitors.

Discovery of 4-Quinazolinone-Containing Phenylalanine Derivatives as Potent, Resistant-Tolerant HIV Capsid Inhibitors.

Journal: MedComm

Published: January 07, 2025

"Pseudosubstrate Envelope"/Free Energy Perturbation-Guided Design and Mechanistic Investigations of Benzothiazole HIV Capsid Modulators with High Ligand Efficiency.

"Pseudosubstrate Envelope"/Free Energy Perturbation-Guided Design and Mechanistic Investigations of Benzothiazole HIV Capsid Modulators with High Ligand Efficiency.

Journal: Journal of medicinal chemistry

Published: October 17, 2024

Discovery, Crystallographic Studies, and Mechanistic Investigations of Novel Phenylalanine Derivatives Bearing a Quinazolin-4-one Scaffold as Potent HIV Capsid Modulators.

Discovery, Crystallographic Studies, and Mechanistic Investigations of Novel Phenylalanine Derivatives Bearing a Quinazolin-4-one Scaffold as Potent HIV Capsid Modulators.

Journal: Journal of medicinal chemistry

Published: December 06, 2023

Opportunities and challenges in new HIV therapeutic discovery: what is the next step?

Opportunities and challenges in new HIV therapeutic discovery: what is the next step?

Journal: Expert opinion on drug discovery

Published: August 10, 2023

Design, synthesis, and mechanistic study of 2-piperazineone-bearing peptidomimetics as novel HIV capsid modulators.

Design, synthesis, and mechanistic study of 2-piperazineone-bearing peptidomimetics as novel HIV capsid modulators.

Journal: RSC medicinal chemistry

Published: March 22, 2023

HIV-1 capsid inhibitors: a sword to destroy the virus.

HIV-1 capsid inhibitors: a sword to destroy the virus.

Journal: Future medicinal chemistry

Published: March 17, 2022

Design, synthesis, and mechanistic investigations of phenylalanine derivatives containing a benzothiazole moiety as HIV-1 capsid inhibitors with improved metabolic stability.

Design, synthesis, and mechanistic investigations of phenylalanine derivatives containing a benzothiazole moiety as HIV-1 capsid inhibitors with improved metabolic stability.

Journal: European journal of medicinal chemistry

Published: September 06, 2021

Design, synthesis, and mechanism study of dimerized phenylalanine derivatives as novel HIV-1 capsid inhibitors.

Design, synthesis, and mechanism study of dimerized phenylalanine derivatives as novel HIV-1 capsid inhibitors.

Journal: European journal of medicinal chemistry

Published: August 03, 2021

Indolylarylsulfones bearing phenylboronic acid and phenylboronate ester functionalities as potent HIV‑1 non-nucleoside reverse transcriptase inhibitors.

Indolylarylsulfones bearing phenylboronic acid and phenylboronate ester functionalities as potent HIV‑1 non-nucleoside reverse transcriptase inhibitors.

Journal: Bioorganic & medicinal chemistry

Published: May 07, 2021

2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 NNRTIs: Rational Design, Synthesis, Activity Evaluation, and Crystallographic Studies.

2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 NNRTIs: Rational Design, Synthesis, Activity Evaluation, and Crystallographic Studies.

Journal: Journal of medicinal chemistry

Published: March 18, 2021

Exploiting the hydrophobic channel of the NNIBP: Discovery of novel diarylpyrimidines as HIV-1 NNRTIs against wild-type and K103N mutant viruses.

Exploiting the hydrophobic channel of the NNIBP: Discovery of novel diarylpyrimidines as HIV-1 NNRTIs against wild-type and K103N mutant viruses.

Journal: Bioorganic & medicinal chemistry

Published: February 06, 2021

Showing 1-12 of 19

Last Updated: 09/26/2026