Linli S. Li

Cancer Center And State Key Laboratory Of Biotherapy
Chengdu, 610041, China

Last Updated: 09/26/2026

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Found 65 publications

Identification of a Potent and Selective Small-Molecule Inhibitor Targeting the nNOS-PDZ Domain that Exhibits Rapid In Vivo Antidepressant Efficacy.

Identification of a Potent and Selective Small-Molecule Inhibitor Targeting the nNOS-PDZ Domain that Exhibits Rapid In Vivo Antidepressant Efficacy.

Journal: Journal of medicinal chemistry

Published: June 03, 2026

Small-molecule inhibition of YTHDC1 as a strategy against acute myeloid leukemia in mouse models.

Small-molecule inhibition of YTHDC1 as a strategy against acute myeloid leukemia in mouse models.

Journal: Science translational medicine

Published: February 04, 2026

Discovery and Structure-Activity Relationship Studies of Diazepine Derivatives as a New Class of Ferroptosis Inhibitors with Potent Efficacy in the Doxorubicin-Induced Cardiomyopathy Model.

Discovery and Structure-Activity Relationship Studies of Diazepine Derivatives as a New Class of Ferroptosis Inhibitors with Potent Efficacy in the Doxorubicin-Induced Cardiomyopathy Model.

Journal: Journal of medicinal chemistry

Published: January 30, 2026

Discovery of a Potent and Selective Cell-Active Inhibitor of Histidine-N1 Methyltransferase METTL9.

Discovery of a Potent and Selective Cell-Active Inhibitor of Histidine-N1 Methyltransferase METTL9.

Journal: Angewandte Chemie (International ed. in English)

Published: January 16, 2026

Discovery and structure-activity relationship analyses of 1,2-diphenylethane derivatives as a new class of GPR68 antagonists and the therapeutic effect in an inflammatory bowel disease model.

Discovery and structure-activity relationship analyses of 1,2-diphenylethane derivatives as a new class of GPR68 antagonists and the therapeutic effect in an inflammatory bowel disease model.

Journal: European journal of medicinal chemistry

Published: December 08, 2025

Discovery of Deuterated 3,4-Dihydro-benzo[e][1,4]diazepine-2,5-dione Derivatives as Potent, Selective and Orally Bioavailable ROCK2 Inhibitors.

Discovery of Deuterated 3,4-Dihydro-benzo[e][1,4]diazepine-2,5-dione Derivatives as Potent, Selective and Orally Bioavailable ROCK2 Inhibitors.

Journal: Journal of medicinal chemistry

Published: November 25, 2025

MSDUNet: A Model Based on Feature Multi-Scale and Dual-Input Dynamic Enhancement for Skin Lesion Segmentation.

MSDUNet: A Model Based on Feature Multi-Scale and Dual-Input Dynamic Enhancement for Skin Lesion Segmentation.

Journal: IEEE transactions on medical imaging

Published: March 07, 2025

Discovery of 4-((quinolin-8-ylthio)methyl)benzamide derivatives as a new class of SARS-CoV-2 nsp13 inhibitors.

Discovery of 4-((quinolin-8-ylthio)methyl)benzamide derivatives as a new class of SARS-CoV-2 nsp13 inhibitors.

Journal: Bioorganic & medicinal chemistry letters

Published: January 27, 2025

Discovery and structure-activity relationship studies of 3-pyridazinesulfonyl derivatives as a new class of inhibitors against NLRP3 inflammasome-dependent pyroptosis.

Discovery and structure-activity relationship studies of 3-pyridazinesulfonyl derivatives as a new class of inhibitors against NLRP3 inflammasome-dependent pyroptosis.

Journal: European journal of medicinal chemistry

Published: January 16, 2025

A Fluorescent Probe Targeting EGFR for the Stratification of Prostate Cancer Cells.

A Fluorescent Probe Targeting EGFR for the Stratification of Prostate Cancer Cells.

Journal: Journal of molecular biology

Published: January 09, 2025

Discovery and structure-activity relationship study of nicotinamide derivatives as DNA demethylase ALKBH2 inhibitors.

Discovery and structure-activity relationship study of nicotinamide derivatives as DNA demethylase ALKBH2 inhibitors.

Journal: European journal of medicinal chemistry

Published: September 10, 2024

Structural Optimization and Structure-Activity Relationship of 1H-Pyrazole-4-carboxylic Acid Derivatives as DNA 6mA Demethylase ALKBH1 Inhibitors and Their Antigastric Cancer Activity.

Structural Optimization and Structure-Activity Relationship of 1H-Pyrazole-4-carboxylic Acid Derivatives as DNA 6mA Demethylase ALKBH1 Inhibitors and Their Antigastric Cancer Activity.

Journal: Journal of medicinal chemistry

Published: September 03, 2024

Showing 1-12 of 65

Last Updated: 09/26/2026