Lloyd G. Czaplewski

7 Denne Hill Business Centre, Womenswold, Kent
Canterbury, ENG CT46HD, United Kingdom

Last Updated: 09/26/2026

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Found 24 publications

Corrigendum to 'Intradiscal linezolid (PP353) treatment for chronic low back pain associated with Modic change type 1: an international, first-in-human, randomised, sham procedure-controlled, double-blind, phase 1b clinical trial' eClinicalMedicine 2026; 92: 103764.

Corrigendum to 'Intradiscal linezolid (PP353) treatment for chronic low back pain associated with Modic change type 1: an international, first-in-human, randomised, sham procedure-controlled, double-blind, phase 1b clinical trial' eClinicalMedicine 2026; 92: 103764.

Journal: EClinicalMedicine
Published: March 20, 2026

Intradiscal linezolid (PP353) treatment for chronic low back pain associated with Modic change type 1: an international, first-in-human, randomised, sham procedure-controlled, double-blind, phase 1b clinical trial.

Intradiscal linezolid (PP353) treatment for chronic low back pain associated with Modic change type 1: an international, first-in-human, randomised, sham procedure-controlled, double-blind, phase 1b clinical trial.

Journal: EClinicalMedicine
Published: August 29, 2025

An overview of global public and philanthropic investments into antibacterial therapeutics (2017-23).

An overview of global public and philanthropic investments into antibacterial therapeutics (2017-23).

Journal: The Lancet. Microbe
Published: April 01, 2025

Multi-year analysis of the global preclinical antibacterial pipeline: trends and gaps.

Multi-year analysis of the global preclinical antibacterial pipeline: trends and gaps.

Journal: Antimicrobial agents and chemotherapy
Published: July 15, 2024

Preclinical development and characterisation of PP353, a formulation of linezolid for intradiscal administration.

Preclinical development and characterisation of PP353, a formulation of linezolid for intradiscal administration.

Journal: JOR spine
Published: April 10, 2024

Pharmacokinetics of PP353, a formulation of linezolid for intervertebral disc administration, in patients with chronic low back pain and Modic change Type 1: A first-in-human, Phase 1b, open-label, single-dose study.

Pharmacokinetics of PP353, a formulation of linezolid for intervertebral disc administration, in patients with chronic low back pain and Modic change Type 1: A first-in-human, Phase 1b, open-label, single-dose study.

Journal: JOR spine
Published: April 10, 2024

Modic changes as seen on MRI are associated with nonspecific chronic lower back pain and disability.

Modic changes as seen on MRI are associated with nonspecific chronic lower back pain and disability.

Journal: Journal of orthopaedic surgery and research
Published: March 03, 2023

Intradiscal pharmacokinetics of oral antibiotics to treat Chronic Lower Back Pain.

Intradiscal pharmacokinetics of oral antibiotics to treat Chronic Lower Back Pain.

Journal: npj antimicrobials and resistance
Published: November 17, 2022

Reply to Kaye and Belley, "Third-Generation Cephalosporin-Resistant Enterobacterales Are Critical Priority Pathogens, Too!"

Reply to Kaye and Belley, "Third-Generation Cephalosporin-Resistant Enterobacterales Are Critical Priority Pathogens, Too!"

Journal: Antimicrobial agents and chemotherapy
Published: March 24, 2022

Analysis of the Clinical Pipeline of Treatments for Drug-Resistant Bacterial Infections: Despite Progress, More Action Is Needed.

Analysis of the Clinical Pipeline of Treatments for Drug-Resistant Bacterial Infections: Despite Progress, More Action Is Needed.

Journal: Antimicrobial agents and chemotherapy
Published: January 10, 2022

Reply to a letter to the editor regarding "Chronic low back pain, bacterial infection and treatment with antibiotics".

Reply to a letter to the editor regarding "Chronic low back pain, bacterial infection and treatment with antibiotics".

Journal: The spine journal : official journal of the North American Spine Society
Published: March 30, 2021

Reply to a letter to the editor regarding the article, "Chronic low back pain, bacterial infection and treatment with antibiotics. Gilligan CJ, Cohen SP, Fischetti VA, Hirsch JA, Czaplewski LG. Spine J 2021 Feb 18;S1529-9430".

Reply to a letter to the editor regarding the article, "Chronic low back pain, bacterial infection and treatment with antibiotics. Gilligan CJ, Cohen SP, Fischetti VA, Hirsch JA, Czaplewski LG. Spine J 2021 Feb 18;S1529-9430".

Journal: The spine journal : official journal of the North American Spine Society
Published: March 30, 2021
Showing 1-12 of 24

Last Updated: 09/26/2026