Longjia Yan

Guiyang, 550025, China

Last Updated: 09/26/2026

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Found 17 publications

Synthesis and biological investigation of phenothiazine-based derivatives as potential HDAC6 inhibitors for treatment of glioblastoma multiforme.

Synthesis and biological investigation of phenothiazine-based derivatives as potential HDAC6 inhibitors for treatment of glioblastoma multiforme.

Journal: Bioorganic & medicinal chemistry letters

Published: May 08, 2026

Design, synthesis, and anti-glioblastoma multiforme evaluation of novel multikinase inhibitors via a cyclization strategy with potent FAK inhibition.

Design, synthesis, and anti-glioblastoma multiforme evaluation of novel multikinase inhibitors via a cyclization strategy with potent FAK inhibition.

Journal: European journal of medicinal chemistry

Published: March 02, 2026

Synthesis and mechanistic investigation of N-Alkoxybenzamide derivatives as EGFR inhibitors.

Synthesis and mechanistic investigation of N-Alkoxybenzamide derivatives as EGFR inhibitors.

Journal: Bioorganic chemistry

Published: November 30, 2025

A tri-channel ratiometric fluorescent probe with dual recognition sites for imaging exogenous and endogenous hypochlorite in living cells.

A tri-channel ratiometric fluorescent probe with dual recognition sites for imaging exogenous and endogenous hypochlorite in living cells.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

Published: October 15, 2025

Discovery of a macrocyclic FAK inhibitor GZD-257 for treatment of glioblastoma.

Discovery of a macrocyclic FAK inhibitor GZD-257 for treatment of glioblastoma.

Journal: Bioorganic & medicinal chemistry letters

Published: July 12, 2025

A novel fluorescent probe for rapid and selective detection of fluoride ions in living cells.

A novel fluorescent probe for rapid and selective detection of fluoride ions in living cells.

Journal: Analytical methods : advancing methods and applications

Published: January 09, 2025

Discovery of noncovalent diaminopyrimidine-based Inhibitors for glioblastoma via a dual FAK/DNA targeting strategy.

Discovery of noncovalent diaminopyrimidine-based Inhibitors for glioblastoma via a dual FAK/DNA targeting strategy.

Journal: European journal of medicinal chemistry

Published: October 20, 2024

Development of a novel fluorescent probe for the Selective and sequential imaging of fluoride and hypochlorite.

Development of a novel fluorescent probe for the Selective and sequential imaging of fluoride and hypochlorite.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

Published: October 14, 2024

Design, Synthesis, and Anti-Leukemic Evaluation of a Series of Dianilinopyrimidines by Regulating the Ras/Raf/MEK/ERK and STAT3/c-Myc Pathways.

Design, Synthesis, and Anti-Leukemic Evaluation of a Series of Dianilinopyrimidines by Regulating the Ras/Raf/MEK/ERK and STAT3/c-Myc Pathways.

Journal: Molecules (Basel, Switzerland)

Published: December 27, 2023

Design, synthesis and antitumor activity of 4-arylamine substituted pyrimidine derivatives as noncovalent EGFR inhibitors overcoming C797S mutation.

Design, synthesis and antitumor activity of 4-arylamine substituted pyrimidine derivatives as noncovalent EGFR inhibitors overcoming C797S mutation.

Journal: European journal of medicinal chemistry

Published: November 27, 2023

Design, synthesis and biological evaluation of 4-arylamino-pyrimidine derivatives as focal adhesion kinase inhibitors.

Design, synthesis and biological evaluation of 4-arylamino-pyrimidine derivatives as focal adhesion kinase inhibitors.

Journal: Bioorganic chemistry

Published: May 06, 2023

Design, synthesis and antitumor activity of 5-trifluoromethylpyrimidine derivatives as EGFR inhibitors.

Design, synthesis and antitumor activity of 5-trifluoromethylpyrimidine derivatives as EGFR inhibitors.

Journal: Journal of enzyme inhibition and medicinal chemistry

Published: September 30, 2022

Showing 1-12 of 17

Last Updated: 09/26/2026