Longjiang Huang

53 Zhengzhou Road
Qingdao, 266042, China

Last Updated: 09/26/2026

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Found 16 publications

Novel 7-Substituted-1,2,4-Triazolopyrimidines targeting Nav1.2 channels as low-neurotoxicity antiepileptic agents.

Novel 7-Substituted-1,2,4-Triazolopyrimidines targeting Nav1.2 channels as low-neurotoxicity antiepileptic agents.

Journal: Bioorganic & medicinal chemistry

Published: November 10, 2025

Novel 5,7-Diazaindole-based ERK5 inhibitor induces endoplasmic reticulum stress and mitochondrial apoptosis in non-small cell lung Cancer.

Novel 5,7-Diazaindole-based ERK5 inhibitor induces endoplasmic reticulum stress and mitochondrial apoptosis in non-small cell lung Cancer.

Journal: Bioorganic chemistry

Published: November 07, 2025

Gu-Jin-Xiao-Ji Decoction potentiates anti-PD-1 immunotherapy in lung cancer by inhibiting the PI3K/AKT/NF-κB/PD-L1 axis.

Gu-Jin-Xiao-Ji Decoction potentiates anti-PD-1 immunotherapy in lung cancer by inhibiting the PI3K/AKT/NF-κB/PD-L1 axis.

Journal: Fitoterapia

Published: October 27, 2025

Pharmacokinetics and Tissue Distribution Study for 2-(2-Fluorophenyl)-5-Phenyl-7-Alkoxy- [1,2,4]Triazole[1,5-a]Pyrimidine Antiepileptic Compounds in Rats.

Pharmacokinetics and Tissue Distribution Study for 2-(2-Fluorophenyl)-5-Phenyl-7-Alkoxy- [1,2,4]Triazole[1,5-a]Pyrimidine Antiepileptic Compounds in Rats.

Journal: Biomedical chromatography : BMC

Published: March 31, 2025

The Potential of PARP Inhibitors as Antitumor Drugs and the Perspective of Molecular Design.

The Potential of PARP Inhibitors as Antitumor Drugs and the Perspective of Molecular Design.

Journal: Journal of medicinal chemistry

Published: December 26, 2024

Discovery of novel 4-azaindole derivatives as selective Nav1.2 Inhibitor with potent antiepileptic activity and low neurotoxicity.

Discovery of novel 4-azaindole derivatives as selective Nav1.2 Inhibitor with potent antiepileptic activity and low neurotoxicity.

Journal: European journal of medicinal chemistry

Published: December 24, 2024

Design, synthesis and structure-activity relationship of novel 1,2,4-triazolopyrimidin-5-one derivatives targeting GABAA1 and Nav1.2 with antiepileptic activity.

Design, synthesis and structure-activity relationship of novel 1,2,4-triazolopyrimidin-5-one derivatives targeting GABAA1 and Nav1.2 with antiepileptic activity.

Journal: European journal of medicinal chemistry

Published: October 14, 2024

Design, synthesis and SAR of novel 7-azaindole derivatives as potential Erk5 kinase inhibitor with anticancer activity.

Design, synthesis and SAR of novel 7-azaindole derivatives as potential Erk5 kinase inhibitor with anticancer activity.

Journal: Bioorganic & medicinal chemistry

Published: August 01, 2023

Design, synthesis, anticonvulsant activity and structure-activity relationships of novel 7-Azaindole derivatives.

Design, synthesis, anticonvulsant activity and structure-activity relationships of novel 7-Azaindole derivatives.

Journal: Bioorganic chemistry

Published: December 22, 2022

Discovery of 7-alkyloxy- [1,2,4] triazolo[1,5-a] pyrimidine derivatives as selective positive modulators of GABAA1 and GABAA4 receptors with potent antiepileptic activity.

Discovery of 7-alkyloxy- [1,2,4] triazolo[1,5-a] pyrimidine derivatives as selective positive modulators of GABAA1 and GABAA4 receptors with potent antiepileptic activity.

Journal: Bioorganic chemistry

Published: October 16, 2021

A novel [1,2,4]triazolo[1,5-a]pyrimidine derivative as a fluorescence probe for specific detection of Fe3+ ions and application in cell imaging.

A novel [1,2,4]triazolo[1,5-a]pyrimidine derivative as a fluorescence probe for specific detection of Fe3+ ions and application in cell imaging.

Journal: Analytica chimica acta

Published: July 30, 2021

Surfactant cocamide monoethanolamide causes eye irritation by activating nociceptor TRPV1 channels.

Surfactant cocamide monoethanolamide causes eye irritation by activating nociceptor TRPV1 channels.

Journal: British journal of pharmacology

Published: September 10, 2020

Showing 1-12 of 16

Last Updated: 09/26/2026