Lorella Pasquinucci

Catania, 95123, Italy

Last Updated: 09/26/2026

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Found 66 publications

PARP1 rewires neuroinflammatory and redox metabolism associated with reactive neuroglia in neuropathic pain.

PARP1 rewires neuroinflammatory and redox metabolism associated with reactive neuroglia in neuropathic pain.

Journal: Redox biology

Published: May 20, 2026

Structure-Guided Repurposing of Approved Drugs Identifies Aprepitant and Mavorixafor as Putative δ-Opioid Receptor Agonist Candidates.

Structure-Guided Repurposing of Approved Drugs Identifies Aprepitant and Mavorixafor as Putative δ-Opioid Receptor Agonist Candidates.

Journal: International journal of molecular sciences

Published: April 03, 2026

Targeting Sigma-1 and Sigma-2 Receptors in Neuropathic Pain: Pharmacology, Ligand Development, and Translational Progress.

Targeting Sigma-1 and Sigma-2 Receptors in Neuropathic Pain: Pharmacology, Ligand Development, and Translational Progress.

Journal: Brain sciences

Published: February 26, 2026

Modulation of Tau Protein Neurotoxic Hallmarks by Novel σ1R Agonists/HDAC Inhibitor Dual-Acting Compounds.

Modulation of Tau Protein Neurotoxic Hallmarks by Novel σ1R Agonists/HDAC Inhibitor Dual-Acting Compounds.

Journal: ChemMedChem

Published: October 16, 2025

Targeting histone deacetylase 1: Inhibition and activation as promising therapeutic strategies for diverse disorders.

Targeting histone deacetylase 1: Inhibition and activation as promising therapeutic strategies for diverse disorders.

Journal: European journal of medicinal chemistry

Published: May 31, 2025

Do vitamins halt the COVID-19-evoked pro-inflammatory cytokines involved in the development of neuropathic pain?

Do vitamins halt the COVID-19-evoked pro-inflammatory cytokines involved in the development of neuropathic pain?

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Published: May 22, 2025

PET imaging of the opioid system using radioligands: Synthetic approaches and translational applications.

PET imaging of the opioid system using radioligands: Synthetic approaches and translational applications.

Journal: European journal of medicinal chemistry

Published: April 01, 2025

The simultaneous activation of μ- and δ-opioid receptors by (-)-2S-LP2 rescues allodynia with the contribution of TGF-β1 signaling in a rat chronic constriction injury model.

The simultaneous activation of μ- and δ-opioid receptors by (-)-2S-LP2 rescues allodynia with the contribution of TGF-β1 signaling in a rat chronic constriction injury model.

Journal: Current research in pharmacology and drug discovery

Published: March 20, 2025

Enhancing HDAC Inhibitor Screening: Addressing Zinc Parameterization and Ligand Protonation in Docking Studies.

Enhancing HDAC Inhibitor Screening: Addressing Zinc Parameterization and Ligand Protonation in Docking Studies.

Journal: International journal of molecular sciences

Published: December 19, 2024

Design and Synthesis of Tetrahydropyrrolo[3,4-c]Pyrazole Sigma-1 Receptor Ligands.

Design and Synthesis of Tetrahydropyrrolo[3,4-c]Pyrazole Sigma-1 Receptor Ligands.

Journal: ChemMedChem

Published: December 18, 2024

Design, Synthesis, and Evaluation of Novel (-)-cis-N-Normetazocine Derivatives: In Vitro and Molecular Modeling Insights.

Design, Synthesis, and Evaluation of Novel (-)-cis-N-Normetazocine Derivatives: In Vitro and Molecular Modeling Insights.

Journal: Chemical biology & drug design

Published: September 16, 2024

Development of selective sigma-1 receptor ligands with antiallodynic activity: A focus on piperidine and piperazine scaffolds.

Development of selective sigma-1 receptor ligands with antiallodynic activity: A focus on piperidine and piperazine scaffolds.

Journal: European journal of medicinal chemistry

Published: September 13, 2024

Showing 1-12 of 66

Last Updated: 09/26/2026