Lorena Leonardelli

Rovereto, Italy

Last Updated: 09/26/2026

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Found 15 publications

Physiologically based pharmacokinetic modeling of mRNA therapeutics: A multiscale framework for LNP and antibody trafficking in mice.

Physiologically based pharmacokinetic modeling of mRNA therapeutics: A multiscale framework for LNP and antibody trafficking in mice.

Journal: Molecular therapy. Nucleic acids

Published: December 24, 2025

A Multiscale Quantitative Systems Pharmacology Model for the Development and Optimization of mRNA Vaccines.

A Multiscale Quantitative Systems Pharmacology Model for the Development and Optimization of mRNA Vaccines.

Journal: CPT: pharmacometrics & systems pharmacology

Published: November 27, 2024

A multiscale physiologically based pharmacokinetic model to support mRNA-encoded BiTE therapy in cancer treatment.

A multiscale physiologically based pharmacokinetic model to support mRNA-encoded BiTE therapy in cancer treatment.

Journal: Molecular therapy. Nucleic acids

Published: October 17, 2024

Computational Analysis of Cytokine Release Following Bispecific T-Cell Engager Therapy: Applications of a Logic-Based Model.

Computational Analysis of Cytokine Release Following Bispecific T-Cell Engager Therapy: Applications of a Logic-Based Model.

Journal: Frontiers in oncology

Published: November 19, 2021

Literature Mining and Mechanistic Graphical Modelling to Improve mRNA Vaccine Platforms.

Literature Mining and Mechanistic Graphical Modelling to Improve mRNA Vaccine Platforms.

Journal: Frontiers in immunology

Published: July 08, 2021

A quantitative systems pharmacology approach to support mRNA vaccine development and optimization.

A quantitative systems pharmacology approach to support mRNA vaccine development and optimization.

Journal: CPT: pharmacometrics & systems pharmacology

Published: July 05, 2021

A QSP model of prostate cancer immunotherapy to identify effective combination therapies.

A QSP model of prostate cancer immunotherapy to identify effective combination therapies.

Journal: Scientific reports

Published: August 13, 2019

A network-based approach to identify deregulated pathways and drug effects in metabolic syndrome.

A network-based approach to identify deregulated pathways and drug effects in metabolic syndrome.

Journal: Nature communications

Published: September 07, 2018

Small supernumerary marker chromosomes: A legacy of trisomy rescue?

Small supernumerary marker chromosomes: A legacy of trisomy rescue?

Journal: Human mutation

Published: August 21, 2018

Dynamics of genetically engineered hematopoietic stem and progenitor cells after autologous transplantation in humans.

Dynamics of genetically engineered hematopoietic stem and progenitor cells after autologous transplantation in humans.

Journal: Nature medicine

Published: April 15, 2018

Preclinical Efficacy and Safety Evaluation of Hematopoietic Stem Cell Gene Therapy in a Mouse Model of MNGIE.

Preclinical Efficacy and Safety Evaluation of Hematopoietic Stem Cell Gene Therapy in a Mouse Model of MNGIE.

Journal: Molecular therapy. Methods & clinical development

Published: October 09, 2017

Current Approaches and Future Perspectives for In Vivo Clonal Tracking of Hematopoietic Cells.

Current Approaches and Future Perspectives for In Vivo Clonal Tracking of Hematopoietic Cells.

Journal: Current gene therapy

Published: December 09, 2015

Showing 1-12 of 15

Last Updated: 09/26/2026