Lorenzo Alamo

Caracas, A 1020, Bolivarian Republic of Venezuela

Last Updated: 09/26/2026

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Found 13 publications

The myosin interacting-heads motif present in live tarantula muscle explains tetanic and posttetanic phosphorylation mechanisms.

The myosin interacting-heads motif present in live tarantula muscle explains tetanic and posttetanic phosphorylation mechanisms.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: May 24, 2020

Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy.

Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy.

Journal: Circulation

Published: January 28, 2020

18O labeling on Ser45 but not on Ser35 supports the cooperative phosphorylation mechanism on tarantula thick filament activation.

18O labeling on Ser45 but not on Ser35 supports the cooperative phosphorylation mechanism on tarantula thick filament activation.

Journal: Biochemical and biophysical research communications

Published: December 15, 2019

Interacting-heads motif has been conserved as a mechanism of myosin II inhibition since before the origin of animals.

Interacting-heads motif has been conserved as a mechanism of myosin II inhibition since before the origin of animals.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: February 16, 2018

Lessons from a tarantula: new insights into myosin interacting-heads motif evolution and its implications on disease.

Lessons from a tarantula: new insights into myosin interacting-heads motif evolution and its implications on disease.

Journal: Biophysical reviews

Published: May 17, 2017

Lessons from a tarantula: new insights into muscle thick filament and myosin interacting-heads motif structure and function.

Lessons from a tarantula: new insights into muscle thick filament and myosin interacting-heads motif structure and function.

Journal: Biophysical reviews

Published: May 17, 2017

Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes.

Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes.

Journal: eLife

Published: December 24, 2016

An invertebrate smooth muscle with striated muscle myosin filaments.

An invertebrate smooth muscle with striated muscle myosin filaments.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: October 08, 2015

Conserved Intramolecular Interactions Maintain Myosin Interacting-Heads Motifs Explaining Tarantula Muscle Super-Relaxed State Structural Basis.

Conserved Intramolecular Interactions Maintain Myosin Interacting-Heads Motifs Explaining Tarantula Muscle Super-Relaxed State Structural Basis.

Journal: Journal of molecular biology

Published: September 11, 2015

Tarantula myosin free head regulatory light chain phosphorylation stiffens N-terminal extension, releasing it and blocking its docking back.

Tarantula myosin free head regulatory light chain phosphorylation stiffens N-terminal extension, releasing it and blocking its docking back.

Journal: Molecular bioSystems

Published: June 04, 2015

A method for 3D-reconstruction of a muscle thick filament using the tilt series images of a single filament electron tomogram.

A method for 3D-reconstruction of a muscle thick filament using the tilt series images of a single filament electron tomogram.

Journal: Journal of structural biology

Published: December 14, 2013

Different head environments in tarantula thick filaments support a cooperative activation process.

Different head environments in tarantula thick filaments support a cooperative activation process.

Journal: Biophysical journal

Published: June 18, 2013

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Last Updated: 09/26/2026