Louie N. Van De Lagemaat

Aberdeen, SCT, United Kingdom

Last Updated: 09/26/2026

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Found 21 publications

RNA terminal uridylyl transferases are druggable vulnerabilities in AML but are dispensable for normal hematopoiesis.

RNA terminal uridylyl transferases are druggable vulnerabilities in AML but are dispensable for normal hematopoiesis.

Journal: Science advances
Published: August 12, 2026

Pan-cancer analysis reveals Rho kinase addiction as a vulnerability of de-differentiated cancer cells.

Pan-cancer analysis reveals Rho kinase addiction as a vulnerability of de-differentiated cancer cells.

Journal: iScience
Published: June 13, 2025

The selective prolyl hydroxylase inhibitor IOX5 stabilizes HIF-1α and compromises development and progression of acute myeloid leukemia.

The selective prolyl hydroxylase inhibitor IOX5 stabilizes HIF-1α and compromises development and progression of acute myeloid leukemia.

Journal: Nature cancer
Published: March 31, 2023

Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death.

Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death.

Journal: Nature communications
Published: May 20, 2022

Intrinsic function of the peptidylarginine deiminase PADI4 is dispensable for normal haematopoiesis.

Intrinsic function of the peptidylarginine deiminase PADI4 is dispensable for normal haematopoiesis.

Journal: Biology open
Published: November 09, 2021

CITED2 coordinates key hematopoietic regulatory pathways to maintain the HSC pool in both steady-state hematopoiesis and transplantation.

CITED2 coordinates key hematopoietic regulatory pathways to maintain the HSC pool in both steady-state hematopoiesis and transplantation.

Journal: Stem cell reports
Published: June 02, 2021

NANOS2 is a sequence-specific mRNA-binding protein that promotes transcript degradation in spermatogonial stem cells.

NANOS2 is a sequence-specific mRNA-binding protein that promotes transcript degradation in spermatogonial stem cells.

Journal: iScience
Published: June 18, 2020

JMJD6 promotes self-renewal and regenerative capacity of hematopoietic stem cells.

JMJD6 promotes self-renewal and regenerative capacity of hematopoietic stem cells.

Journal: Blood advances
Published: June 17, 2020

The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function.

The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function.

Journal: The Journal of experimental medicine
Published: April 28, 2020

CpG binding protein (CFP1) occupies open chromatin regions of active genes, including enhancers and non-CpG islands.

CpG binding protein (CFP1) occupies open chromatin regions of active genes, including enhancers and non-CpG islands.

Journal: Epigenetics & chromatin
Published: July 13, 2018

Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia.

Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia.

Journal: Cell stem cell
Published: May 04, 2018

Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions.

Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions.

Journal: The Journal of experimental medicine
Published: July 12, 2016
Showing 1-12 of 21

Last Updated: 09/26/2026