Luc Brunsveld

Eindhoven, NB 5600MB, Netherlands

Last Updated: 09/26/2026

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Found 147 publications

Molecular Glue and Phosphorylation-Dependent 14-3-3 Recruitment to p53 with an Engineered Interaction Cassette.

Molecular Glue and Phosphorylation-Dependent 14-3-3 Recruitment to p53 with an Engineered Interaction Cassette.

Journal: ACS chemical biology
Published: May 25, 2026

A Molecular Mechanistic Deep Dive into 14-3-3 Molecular Glue Cooperativity.

A Molecular Mechanistic Deep Dive into 14-3-3 Molecular Glue Cooperativity.

Journal: Biochemistry
Published: May 21, 2026

Restoring the 14-3-3/CRAF regulatory interaction in Noonan syndrome using molecular glues.

Restoring the 14-3-3/CRAF regulatory interaction in Noonan syndrome using molecular glues.

Journal: Proceedings of the National Academy of Sciences of the United States of America
Published: April 28, 2026

Induced ubiquitination of the partially disordered estrogen receptor alpha via a 14-3-3 directed molecular glue-PROTAC.

Induced ubiquitination of the partially disordered estrogen receptor alpha via a 14-3-3 directed molecular glue-PROTAC.

Journal: Nature communications
Published: November 24, 2025

Macrocyclic Molecular Glues for the 14-3-3/ChREBP Interaction: Affinity and Cooperativity in an Inverse Relationship.

Macrocyclic Molecular Glues for the 14-3-3/ChREBP Interaction: Affinity and Cooperativity in an Inverse Relationship.

Journal: Angewandte Chemie (International ed. in English)
Published: October 05, 2025

Structural Elucidation and Covalent Modulation of the Autorepressed Orphan Nuclear Receptor NR2F6.

Structural Elucidation and Covalent Modulation of the Autorepressed Orphan Nuclear Receptor NR2F6.

Journal: ACS chemical biology
Published: September 10, 2025

Modulation of the 14-3-3σ/C-RAF "auto"inhibited complex by molecular glues.

Modulation of the 14-3-3σ/C-RAF "auto"inhibited complex by molecular glues.

Journal: bioRxiv : the preprint server for biology
Published: August 06, 2025

Stoichiometric 14-3-3ζ binding promotes phospho-Tau microtubule dissociation and reduces aggregation and condensation.

Stoichiometric 14-3-3ζ binding promotes phospho-Tau microtubule dissociation and reduces aggregation and condensation.

Journal: Communications biology
Published: June 14, 2025

Identifying 14-3-3 interactome binding sites with deep learning.

Identifying 14-3-3 interactome binding sites with deep learning.

Journal: Digital discovery
Published: March 31, 2025

Scaffold-hopping for molecular glues targeting the 14-3-3/ERα complex.

Scaffold-hopping for molecular glues targeting the 14-3-3/ERα complex.

Journal: Nature communications
Published: February 17, 2025

Automated navigation of condensate phase behavior with active machine learning.

Automated navigation of condensate phase behavior with active machine learning.

Journal: Nature communications
Published: November 30, 2024

Proximity-enhanced cysteine-histidine crosslinking for elucidating intrinsically disordered and other protein complexes.

Proximity-enhanced cysteine-histidine crosslinking for elucidating intrinsically disordered and other protein complexes.

Journal: Chemical science
Published: November 02, 2024
Showing 1-12 of 147

Last Updated: 09/26/2026