Luc Tritsmans

Beerse, VLG 2340, Belgium

Last Updated: 09/26/2026

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Found 17 publications

Discovery of Atabecestat (JNJ-54861911): A Thiazine-Based β-Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor Advanced to the Phase 2b/3 EARLY Clinical Trial.

Discovery of Atabecestat (JNJ-54861911): A Thiazine-Based β-Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor Advanced to the Phase 2b/3 EARLY Clinical Trial.

Journal: Journal of medicinal chemistry

Published: February 16, 2021

Long-term safety and tolerability of atabecestat (JNJ-54861911), an oral BACE1 inhibitor, in early Alzheimer's disease spectrum patients: a randomized, double-blind, placebo-controlled study and a two-period extension study.

Long-term safety and tolerability of atabecestat (JNJ-54861911), an oral BACE1 inhibitor, in early Alzheimer's disease spectrum patients: a randomized, double-blind, placebo-controlled study and a two-period extension study.

Journal: Alzheimer's research & therapy

Published: February 04, 2020

Relevance of the interplay between amyloid and tau for cognitive impairment in early Alzheimer's disease.

Relevance of the interplay between amyloid and tau for cognitive impairment in early Alzheimer's disease.

Journal: Neurobiology of aging

Published: December 14, 2018

Pharmacodynamics of atabecestat (JNJ-54861911), an oral BACE1 inhibitor in patients with early Alzheimer's disease: randomized, double-blind, placebo-controlled study.

Pharmacodynamics of atabecestat (JNJ-54861911), an oral BACE1 inhibitor in patients with early Alzheimer's disease: randomized, double-blind, placebo-controlled study.

Journal: Alzheimer's research & therapy

Published: March 29, 2018

Evaluating Potential QT Effects of JNJ-54861911, a BACE Inhibitor in Single- and Multiple-Ascending Dose Studies, and a Thorough QT Trial With Additional Retrospective Confirmation, Using Concentration-QTc Analysis.

Evaluating Potential QT Effects of JNJ-54861911, a BACE Inhibitor in Single- and Multiple-Ascending Dose Studies, and a Thorough QT Trial With Additional Retrospective Confirmation, Using Concentration-QTc Analysis.

Journal: Journal of clinical pharmacology

Published: November 21, 2017

BACE1 Dynamics Upon Inhibition with a BACE Inhibitor and Correlation to Downstream Alzheimer's Disease Markers in Elderly Healthy Participants.

BACE1 Dynamics Upon Inhibition with a BACE Inhibitor and Correlation to Downstream Alzheimer's Disease Markers in Elderly Healthy Participants.

Journal: Journal of Alzheimer's disease : JAD

Published: February 04, 2017

Profiling the dynamics of CSF and plasma Aβ reduction after treatment with JNJ-54861911, a potent oral BACE inhibitor.

Profiling the dynamics of CSF and plasma Aβ reduction after treatment with JNJ-54861911, a potent oral BACE inhibitor.

Journal: Alzheimer's & dementia (New York, N. Y.)

Published: August 24, 2016

Characterization of Rabbit Antibodies Against the Immunogenic JC Polyomavirus Peptide JCPyV_VP2_167-15mer.

Characterization of Rabbit Antibodies Against the Immunogenic JC Polyomavirus Peptide JCPyV_VP2_167-15mer.

Journal: Viral immunology

Published: June 16, 2015

JC virus quasispecies analysis reveals a complex viral population underlying progressive multifocal leukoencephalopathy and supports viral dissemination via the hematogenous route.

JC virus quasispecies analysis reveals a complex viral population underlying progressive multifocal leukoencephalopathy and supports viral dissemination via the hematogenous route.

Journal: Journal of virology

Published: November 14, 2014

Antibodies reacting with JCPyV_VP2 _167-15mer as a novel serological marker for JC polyomavirus infection.

Antibodies reacting with JCPyV_VP2 _167-15mer as a novel serological marker for JC polyomavirus infection.

Journal: Virology journal

Published: June 26, 2014

Viral miRNAs in plasma and urine divulge JC polyomavirus infection.

Viral miRNAs in plasma and urine divulge JC polyomavirus infection.

Journal: Virology journal

Published: June 18, 2014

Circulating human microRNAs are not linked to JC polyomavirus serology or urinary viral load in healthy subjects.

Circulating human microRNAs are not linked to JC polyomavirus serology or urinary viral load in healthy subjects.

Journal: Virology journal

Published: December 23, 2013

Showing 1-12 of 17

Last Updated: 09/26/2026