Luca C. Gobbi

Basel, BS 4070, Switzerland

Last Updated: 09/26/2026

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Found 32 publications

Discovery of the First Brain-Penetrant Radioligands for Visualizing the GABA Transporter 1 (GAT-1): Synthesis, In Vitro Screening, and In Vivo Evaluation in Nonhuman Primates.

Discovery of the First Brain-Penetrant Radioligands for Visualizing the GABA Transporter 1 (GAT-1): Synthesis, In Vitro Screening, and In Vivo Evaluation in Nonhuman Primates.

Journal: Journal of medicinal chemistry

Published: April 07, 2026

Pretargeted Immuno-PET Enables Monoclonal Antibody Imaging Beyond the Blood-Brain Barrier.

Pretargeted Immuno-PET Enables Monoclonal Antibody Imaging Beyond the Blood-Brain Barrier.

Journal: Molecular pharmaceutics

Published: November 06, 2025

Tritium-Labeled Compounds in PET Tracer Discovery? A Case Study from Roche's Internal Monoacylglycerol Lipase Program.

Tritium-Labeled Compounds in PET Tracer Discovery? A Case Study from Roche's Internal Monoacylglycerol Lipase Program.

Journal: ACS chemical neuroscience

Published: September 18, 2025

Preclinical development of [18F]TAAR1-2203 as a PET radioligand for imaging TAAR1 expression and receptor occupancy.

Preclinical development of [18F]TAAR1-2203 as a PET radioligand for imaging TAAR1 expression and receptor occupancy.

Journal: European journal of nuclear medicine and molecular imaging

Published: July 07, 2025

Translational molecular imaging and drug development in multiple sclerosis.

Translational molecular imaging and drug development in multiple sclerosis.

Journal: Theranostics

Published: June 14, 2025

Toward Imaging of the GABA Transporter Type 1 In Vivo: Quantitative Evaluation of 4 Novel PET Radiotracers in Nonhuman Primates.

Toward Imaging of the GABA Transporter Type 1 In Vivo: Quantitative Evaluation of 4 Novel PET Radiotracers in Nonhuman Primates.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Published: May 06, 2025

The "five-star matrix" for patient-centric drug discovery and development in neuroscience.

The "five-star matrix" for patient-centric drug discovery and development in neuroscience.

Journal: Neuron

Published: February 02, 2025

Characterization of [3H]AZ12464237 as a high affinity, non-nucleotide antagonist radioligand for the P2Y12 receptor.

Characterization of [3H]AZ12464237 as a high affinity, non-nucleotide antagonist radioligand for the P2Y12 receptor.

Journal: Biochemical pharmacology

Published: November 11, 2024

Structure-Guided Discovery of cis-Hexahydro-pyrido-oxazinones as Reversible, Drug-like Monoacylglycerol Lipase Inhibitors.

Structure-Guided Discovery of cis-Hexahydro-pyrido-oxazinones as Reversible, Drug-like Monoacylglycerol Lipase Inhibitors.

Journal: Journal of medicinal chemistry

Published: October 03, 2024

Exploration of (R)-[11C]YH168 as a PET tracer for imaging monoacylglycerol lipase in the brain: from mice to non-human primates.

Exploration of (R)-[11C]YH168 as a PET tracer for imaging monoacylglycerol lipase in the brain: from mice to non-human primates.

Journal: European journal of nuclear medicine and molecular imaging

Published: September 09, 2024

Development of a Highly Selective NanoBRET Probe to Assess MAGL Inhibition in Live Cells.

Development of a Highly Selective NanoBRET Probe to Assess MAGL Inhibition in Live Cells.

Journal: Chembiochem : a European journal of chemical biology

Published: August 27, 2024

Enhancing Drug Discovery and Development through the Integration of Medicinal Chemistry, Chemical Biology, and Academia-Industry Partnerships: Insights from Roche's Endocannabinoid System Projects.

Enhancing Drug Discovery and Development through the Integration of Medicinal Chemistry, Chemical Biology, and Academia-Industry Partnerships: Insights from Roche's Endocannabinoid System Projects.

Journal: Chimia

Published: June 09, 2024

Showing 1-12 of 32

Last Updated: 09/26/2026