Lucia Kovacikova - Publications

Design of fluorinated triazinoindoles as highly potent and markedly selective ALR2 inhibitors: synthesis, in silico and in vitro evaluation of promising lead compounds.

Journal: Bioorganic chemistry

Published: May 18, 2026

Rational design and synthesis of novel N-benzylindole-based epalrestat analogs as selective aldose reductase inhibitors: An unexpected discovery of a new glucose-lowering agent (AK-4) acting as a mitochondrial uncoupler.

Journal: European journal of medicinal chemistry

Published: September 23, 2024

Cemtirestat dimerization in liposomes and erythrocytes exposed to peroxyl radicals was reverted by thiol-disulfide exchange with GSH.

Journal: Free radical research

Published: December 25, 2023

Inhibitors of SARS-CoV-2 main protease: Biological efficacy and toxicity aspects.

Journal: Toxicology in vitro : an international journal published in association with BIBRA

Published: April 18, 2023

Novel rhodanine based inhibitors of aldose reductase of non-acidic nature with p-hydroxybenzylidene functional group.

Journal: European journal of medicinal chemistry

Published: July 25, 2022

Non-acidic bifunctional benzothiazole-based thiazolidinones with antimicrobial and aldose reductase inhibitory activity as a promising therapeutic strategy for sepsis.

Journal: Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents

Published: June 17, 2021

Development of Novel Indole-Based Bifunctional Aldose Reductase Inhibitors/Antioxidants as Promising Drugs for the Treatment of Diabetic Complications.

Journal: Molecules (Basel, Switzerland)

Published: March 29, 2021

Non-carboxylic acid inhibitors of aldose reductase based on N-substituted thiazolidinedione derivatives.

Journal: European journal of medicinal chemistry

Published: February 06, 2021

Novel substituted N-benzyl(oxotriazinoindole) inhibitors of aldose reductase exploiting ALR2 unoccupied interactive pocket.

Journal: Bioorganic & medicinal chemistry

Published: August 27, 2020

Antioxidant Mechanisms in the Neuroprotective Action of Cemtirestat: Studies in Chemical Models, Liposomes and Rat Brain Cortical Slices.

Journal: Neuroscience

Published: May 04, 2020

Design synthesis and evaluation of novel aldose reductase inhibitors: The case of indolyl-sulfonyl-phenols.

Journal: Bioorganic & medicinal chemistry

Published: February 17, 2020

Development of Novel Oxotriazinoindole Inhibitors of Aldose Reductase: Isosteric Sulfur/Oxygen Replacement in the Thioxotriazinoindole Cemtirestat Markedly Improved Inhibition Selectivity.

Journal: Journal of medicinal chemistry

Published: December 11, 2019