Luis Ornelas-Fonseca

Goettingen, NI, Germany

Last Updated: 09/26/2026

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Found 15 publications

Lipid membrane remodeling by myristic acid treatment reverses Parkinson's disease α-synuclein phenotypes in patient neurons.

Lipid membrane remodeling by myristic acid treatment reverses Parkinson's disease α-synuclein phenotypes in patient neurons.

Journal: npj metabolic health and disease

Published: March 12, 2025

Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity.

Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity.

Journal: NPJ Parkinson's disease

Published: July 12, 2022

Parkinson-causing mutations in LRRK2 impair the physiological tetramerization of endogenous α-synuclein in human neurons.

Parkinson-causing mutations in LRRK2 impair the physiological tetramerization of endogenous α-synuclein in human neurons.

Journal: NPJ Parkinson's disease

Published: January 24, 2022

Altered conformation of α-synuclein drives dysfunction of synaptic vesicles in a synaptosomal model of Parkinson's disease.

Altered conformation of α-synuclein drives dysfunction of synaptic vesicles in a synaptosomal model of Parkinson's disease.

Journal: Cell reports

Published: August 21, 2020

E46K-like α-synuclein mutants increase lipid interactions and disrupt membrane selectivity.

E46K-like α-synuclein mutants increase lipid interactions and disrupt membrane selectivity.

Journal: The Journal of biological chemistry

Published: November 09, 2018

Nuclear localization and phosphorylation modulate pathological effects of alpha-synuclein.

Nuclear localization and phosphorylation modulate pathological effects of alpha-synuclein.

Journal: Human molecular genetics

Published: June 25, 2018

Refolding of helical soluble α-synuclein through transient interaction with lipid interfaces.

Refolding of helical soluble α-synuclein through transient interaction with lipid interfaces.

Journal: FEBS letters

Published: March 23, 2018

Small-Molecule-Induced Soluble Oligomers of α-Synuclein with Helical Structure.

Small-Molecule-Induced Soluble Oligomers of α-Synuclein with Helical Structure.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany)

Published: June 29, 2017

Correction: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.

Correction: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.

Journal: PLoS biology

Published: April 06, 2017

Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity.

Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: October 07, 2016

The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.

The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.

Journal: PLoS biology

Published: June 21, 2016

Fasudil attenuates aggregation of α-synuclein in models of Parkinson's disease.

Fasudil attenuates aggregation of α-synuclein in models of Parkinson's disease.

Journal: Acta neuropathologica communications

Published: April 09, 2016

Showing 1-12 of 15

Last Updated: 09/26/2026