Lukas Schmidheini
Zurich, ZH, Switzerland
Last Updated: 09/26/2026
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Found 12 publications
Prime editing of a pathogenic Scn1a allele ameliorates seizure phenotypes in a GEFS+ mouse model.
Journal: Science translational medicine
Published: May 13, 2026
Prime editing of the β1 adrenoceptor in the brain restores physiological REM sleep in a mouse model of Alzheimer's disease.
Journal: Nature communications
Published: March 05, 2025
Treatment of a metabolic liver disease in mice with a transient prime editing approach.
Journal: Nature biomedical engineering
Published: January 14, 2024
Machine learning prediction of prime editing efficiency across diverse chromatin contexts.
Journal: Nature biotechnology
Published: October 08, 2023
Effective genome editing with an enhanced ISDra2 TnpB system and deep learning-predicted ωRNAs.
Journal: Nature methods
Published: October 04, 2023
Continuous directed evolution of a compact CjCas9 variant with broad PAM compatibility.
Journal: Nature chemical biology
Published: December 08, 2022
Predicting prime editing efficiency and product purity by deep learning.
Journal: Nature biotechnology
Published: April 05, 2022
In vivo prime editing of a metabolic liver disease in mice.
Journal: Science translational medicine
Published: March 16, 2022
Self-Assembly of Nanodiamonds and Plasmonic Nanoparticles for Nanoscopy.
Journal: Biosensors
Published: January 27, 2022
Replacing the SpCas9 HNH domain by deaminases generates compact base editors with an alternative targeting scope.
Journal: Molecular therapy. Nucleic acids
Published: December 21, 2020
Showing 1-12 of 12
Last Updated: 09/26/2026