Luke H. Chamberlain

Glasgow, SCT, United Kingdom

Last Updated: 09/26/2026

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Found 35 publications

The GCP16-zDHHC9 S-acyltransferase complex: reciprocal effects on protein S-acylation and stability.

The GCP16-zDHHC9 S-acyltransferase complex: reciprocal effects on protein S-acylation and stability.

Journal: The Journal of biological chemistry

Published: February 01, 2026

Different chains for different gains: How acyl chain diversity shapes S-acylated protein function.

Different chains for different gains: How acyl chain diversity shapes S-acylated protein function.

Journal: Progress in lipid research

Published: May 05, 2025

Quantitative analysis of protein lipidation and acyl-CoAs reveals substrate preferences of the S-acylation machinery.

Quantitative analysis of protein lipidation and acyl-CoAs reveals substrate preferences of the S-acylation machinery.

Journal: Chemical science

Published: April 04, 2024

The endoplasmic reticulum-localized enzyme zDHHC6 mediates S-acylation of short transmembrane constructs from multiple type I and II membrane proteins.

The endoplasmic reticulum-localized enzyme zDHHC6 mediates S-acylation of short transmembrane constructs from multiple type I and II membrane proteins.

Journal: The Journal of biological chemistry

Published: June 26, 2023

S-acylation of Sprouty and SPRED proteins by the S-acyltransferase zDHHC17 involves a novel mode of enzyme-substrate interaction.

S-acylation of Sprouty and SPRED proteins by the S-acyltransferase zDHHC17 involves a novel mode of enzyme-substrate interaction.

Journal: The Journal of biological chemistry

Published: October 14, 2022

The Hydrophobic Cysteine-rich Domain of SNAP25 Couples with Downstream Residues to Mediate Membrane Interactions and Recognition by DHHC Palmitoyl Transferases.

The Hydrophobic Cysteine-rich Domain of SNAP25 Couples with Downstream Residues to Mediate Membrane Interactions and Recognition by DHHC Palmitoyl Transferases.

Journal: Molecular biology of the cell

Published: August 18, 2022

Development of a novel high-throughput screen for the identification of new inhibitors of protein S-acylation.

Development of a novel high-throughput screen for the identification of new inhibitors of protein S-acylation.

Journal: The Journal of biological chemistry

Published: March 18, 2022

Regulatory effects of protein S-acylation on insulin secretion and insulin action.

Regulatory effects of protein S-acylation on insulin secretion and insulin action.

Journal: Open biology

Published: March 31, 2021

Accessory proteins of the zDHHC family of S-acylation enzymes.

Accessory proteins of the zDHHC family of S-acylation enzymes.

Journal: Journal of cell science

Published: November 18, 2020

Regulatory effects of post-translational modifications on zDHHC S-acyltransferases.

Regulatory effects of post-translational modifications on zDHHC S-acyltransferases.

Journal: The Journal of biological chemistry

Published: June 22, 2020

Identification of key features required for efficient S-acylation and plasma membrane targeting of sprouty-2.

Identification of key features required for efficient S-acylation and plasma membrane targeting of sprouty-2.

Journal: Journal of cell science

Published: May 29, 2020

The linker domain of the SNARE protein SNAP25 acts as a flexible molecular spacer that ensures efficient S-acylation.

The linker domain of the SNARE protein SNAP25 acts as a flexible molecular spacer that ensures efficient S-acylation.

Journal: The Journal of biological chemistry

Published: January 20, 2020

Showing 1-12 of 35

Last Updated: 09/26/2026