Lydia M. Castelli

385 Glossop Road
Sheffield, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 33 publications

Senescence Markers and Associated Transcriptomic Changes Are Expressed at Early Stages of Alzheimer's Neuropathology but Are Not Independently Related to Dementia.

Senescence Markers and Associated Transcriptomic Changes Are Expressed at Early Stages of Alzheimer's Neuropathology but Are Not Independently Related to Dementia.

Journal: International journal of molecular sciences

Published: July 01, 2026

Antisense Dipeptide Repeat Proteins Drive Widescale Purine Metabolism Aberration in C9orf72 Amyotrophic Lateral Sclerosis via ADA.

Antisense Dipeptide Repeat Proteins Drive Widescale Purine Metabolism Aberration in C9orf72 Amyotrophic Lateral Sclerosis via ADA.

Journal: International journal of molecular sciences

Published: January 25, 2026

From use of omics to systems biology: Identifying therapeutic targets for amyotrophic lateral sclerosis.

From use of omics to systems biology: Identifying therapeutic targets for amyotrophic lateral sclerosis.

Journal: International review of neurobiology

Published: May 27, 2024

RuvBL1/2 reduce toxic dipeptide repeat protein burden in multiple models of C9orf72-ALS/FTD.

RuvBL1/2 reduce toxic dipeptide repeat protein burden in multiple models of C9orf72-ALS/FTD.

Journal: Life science alliance

Published: April 05, 2024

RAN Translation of C9orf72-Related Dipeptide Repeat Proteins in Zebrafish Recapitulates Hallmarks of Amyotrophic Lateral Sclerosis and Identifies Hypothermia as a Therapeutic Strategy.

RAN Translation of C9orf72-Related Dipeptide Repeat Proteins in Zebrafish Recapitulates Hallmarks of Amyotrophic Lateral Sclerosis and Identifies Hypothermia as a Therapeutic Strategy.

Journal: Annals of neurology

Published: February 14, 2024

Translation factor and RNA binding protein mRNA interactomes support broader RNA regulons for posttranscriptional control.

Translation factor and RNA binding protein mRNA interactomes support broader RNA regulons for posttranscriptional control.

Journal: The Journal of biological chemistry

Published: July 07, 2023

A cell-penetrant peptide blocking C9ORF72-repeat RNA nuclear export reduces the neurotoxic effects of dipeptide repeat proteins.

A cell-penetrant peptide blocking C9ORF72-repeat RNA nuclear export reduces the neurotoxic effects of dipeptide repeat proteins.

Journal: Science translational medicine

Published: March 01, 2023

A Y374X TDP43 truncation leads to an altered metabolic profile in amyotrophic lateral sclerosis fibroblasts driven by pyruvate and TCA cycle intermediate alterations.

A Y374X TDP43 truncation leads to an altered metabolic profile in amyotrophic lateral sclerosis fibroblasts driven by pyruvate and TCA cycle intermediate alterations.

Journal: Frontiers in aging neuroscience

Published: January 26, 2023

Loss of TMEM106B exacerbates C9ALS/FTD DPR pathology by disrupting autophagosome maturation.

Loss of TMEM106B exacerbates C9ALS/FTD DPR pathology by disrupting autophagosome maturation.

Journal: Frontiers in cellular neuroscience

Published: October 04, 2022

Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication.

Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication.

Journal: Life science alliance

Published: March 15, 2022

RNA Helicases in Microsatellite Repeat Expansion Disorders and Neurodegeneration.

RNA Helicases in Microsatellite Repeat Expansion Disorders and Neurodegeneration.

Journal: Frontiers in genetics

Published: February 28, 2022

The master energy homeostasis regulator PGC-1α exhibits an mRNA nuclear export function.

The master energy homeostasis regulator PGC-1α exhibits an mRNA nuclear export function.

Journal: Nature communications

Published: February 02, 2022

Showing 1-12 of 33

Last Updated: 09/26/2026