Lyn-marie Birkholtz

Lynnwood Road
Pretoria, GT 0028, South Africa

Last Updated: 09/26/2026

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Found 109 publications

The Human Chk1 Inhibitor CHIR-124 Shows Multistage Activity against the Human Malaria Parasite Plasmodium falciparum via Polypharmacological Inhibition of PfArk1 and Hemozoin Formation.

The Human Chk1 Inhibitor CHIR-124 Shows Multistage Activity against the Human Malaria Parasite Plasmodium falciparum via Polypharmacological Inhibition of PfArk1 and Hemozoin Formation.

Journal: ACS chemical biology

Published: June 13, 2026

Structure-Guided Optimization of Novel Inhibitors of Plasmodium Lysyl-tRNA Synthetase with Multistage Activity against Malaria Parasites.

Structure-Guided Optimization of Novel Inhibitors of Plasmodium Lysyl-tRNA Synthetase with Multistage Activity against Malaria Parasites.

Journal: Journal of medicinal chemistry

Published: June 02, 2026

Potent reaction hijacking inhibitors of Plasmodium falciparum asparagine tRNA synthetase.

Potent reaction hijacking inhibitors of Plasmodium falciparum asparagine tRNA synthetase.

Journal: bioRxiv : the preprint server for biology

Published: May 25, 2026

Potent reaction hijacking inhibitors of Plasmodium falciparum asparagine tRNA synthetase.

Potent reaction hijacking inhibitors of Plasmodium falciparum asparagine tRNA synthetase.

Journal: bioRxiv : the preprint server for biology

Published: May 25, 2026

Protein Arginine Methyltransferase Inhibitors Target Multiple Stages of Plasmodium falciparum Parasites In Vitro.

Protein Arginine Methyltransferase Inhibitors Target Multiple Stages of Plasmodium falciparum Parasites In Vitro.

Journal: ACS infectious diseases

Published: March 31, 2026

Targeted protein degradation as a novel therapeutic strategy against infectious diseases.

Targeted protein degradation as a novel therapeutic strategy against infectious diseases.

Journal: Current opinion in chemical biology

Published: November 23, 2025

A Novel Class of Orally Bioavailable Phenylglycine-Benzoxaborole Conjugates with Antimalarial Activity and Potentially Novel Mechanism of Action.

A Novel Class of Orally Bioavailable Phenylglycine-Benzoxaborole Conjugates with Antimalarial Activity and Potentially Novel Mechanism of Action.

Journal: ACS medicinal chemistry letters

Published: September 15, 2025

Targeting Aurora Kinases as Essential Cell-Cycle Regulators to Deliver Multi-Stage Antimalarials Against Plasmodium Falciparum.

Targeting Aurora Kinases as Essential Cell-Cycle Regulators to Deliver Multi-Stage Antimalarials Against Plasmodium Falciparum.

Journal: Angewandte Chemie (International ed. in English)

Published: August 22, 2025

Novel Inhibitors of Plasmodium Phosphatidylinositol 4-kinase IIIβ with Low Propensity for Resistance: Life Cycle Stage Activity and In Vivo Efficacy in a Humanized Mouse Malaria Infection Model.

Novel Inhibitors of Plasmodium Phosphatidylinositol 4-kinase IIIβ with Low Propensity for Resistance: Life Cycle Stage Activity and In Vivo Efficacy in a Humanized Mouse Malaria Infection Model.

Journal: Journal of medicinal chemistry

Published: August 14, 2025

The Human Chk1 Inhibitor CHIR-124 Shows Multistage Activity Against Plasmodium falciparum via Dual Inhibition of PfArk1 and Hemozoin Formation.

The Human Chk1 Inhibitor CHIR-124 Shows Multistage Activity Against Plasmodium falciparum via Dual Inhibition of PfArk1 and Hemozoin Formation.

Journal: bioRxiv : the preprint server for biology

Published: August 12, 2025

Ferrocenyl Quinoline-Benzimidazole Hybrids: A Multistage Strategy to Combat Drug-Resistant Malaria.

Ferrocenyl Quinoline-Benzimidazole Hybrids: A Multistage Strategy to Combat Drug-Resistant Malaria.

Journal: Inorganic chemistry

Published: July 31, 2025

Characterizing the quick-killing mechanism of action of azithromycin analogs against malaria parasites.

Characterizing the quick-killing mechanism of action of azithromycin analogs against malaria parasites.

Journal: Antimicrobial agents and chemotherapy

Published: July 25, 2025

Showing 1-12 of 109

Last Updated: 09/26/2026