Mahmoud S. Elkotamy

Badr, C 11829, Egypt

Last Updated: 09/26/2026

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Found 31 publications

Striking two targets with one scaffold via benzo[d]imidazole-isatin conjugates as potent dual VEGFR-2/c-MET antagonists.

Striking two targets with one scaffold via benzo[d]imidazole-isatin conjugates as potent dual VEGFR-2/c-MET antagonists.

Journal: Bioorganic & medicinal chemistry

Published: June 27, 2026

1-Butylindoline-2,3-dione derivatives as potent VEGFR-2 inhibitors: synthesis, mechanistic anticancer studies, and molecular dynamics simulations.

1-Butylindoline-2,3-dione derivatives as potent VEGFR-2 inhibitors: synthesis, mechanistic anticancer studies, and molecular dynamics simulations.

Journal: RSC advances

Published: June 13, 2026

Design and Synthesis of Indole-Based Imidazo[1,2-a]pyridine Derivatives as Antiseizure Candidates: Evaluation in Chemically Induced Seizure Models and In Vitro Antioxidant Assays.

Design and Synthesis of Indole-Based Imidazo[1,2-a]pyridine Derivatives as Antiseizure Candidates: Evaluation in Chemically Induced Seizure Models and In Vitro Antioxidant Assays.

Journal: ACS chemical neuroscience

Published: May 15, 2026

Identification of Sulfonamide-Based Thiazolidine-2,4-Dione Derivatives as VEGFR-2 and Tumor-Associated hCA IX Inhibitors With Hypoxia-Targeted Anti-Colorectal Cancer Activity.

Identification of Sulfonamide-Based Thiazolidine-2,4-Dione Derivatives as VEGFR-2 and Tumor-Associated hCA IX Inhibitors With Hypoxia-Targeted Anti-Colorectal Cancer Activity.

Journal: Drug development research

Published: April 08, 2026

Unlocking the antidiabetic potential of novel pyrazole-triazole hybrids through synthesis, dual α-amylase/α-glucosidase inhibition, multiscale biological evaluation, and molecular dynamics studies.

Unlocking the antidiabetic potential of novel pyrazole-triazole hybrids through synthesis, dual α-amylase/α-glucosidase inhibition, multiscale biological evaluation, and molecular dynamics studies.

Journal: RSC advances

Published: April 02, 2026

Thiadiazole-Derived VEGFR-2 Inhibitors: From Design to Anticancer Evaluation.

Thiadiazole-Derived VEGFR-2 Inhibitors: From Design to Anticancer Evaluation.

Journal: Chemical biology & drug design

Published: February 03, 2026

Click chemistry synthesis of triazole-grafted quinazolinones as new multi-panel anticancer agents: mechanistic insights into apoptosis and cell cycle arrest in colorectal cancer.

Click chemistry synthesis of triazole-grafted quinazolinones as new multi-panel anticancer agents: mechanistic insights into apoptosis and cell cycle arrest in colorectal cancer.

Journal: Bioorganic chemistry

Published: February 02, 2026

Structure-guided design and synthesis of Etoricoxib analogues for selective COX-2 inhibition: in vitro assessment and computational insights with prospective in vivo confirmation.

Structure-guided design and synthesis of Etoricoxib analogues for selective COX-2 inhibition: in vitro assessment and computational insights with prospective in vivo confirmation.

Journal: Molecular diversity

Published: January 31, 2026

Multi-target pyrazolopyrimidine-coumarin derivatives as potent CA IX/XII and tubulin polymerization inhibitors: Design, synthesis, and biological evaluation.

Multi-target pyrazolopyrimidine-coumarin derivatives as potent CA IX/XII and tubulin polymerization inhibitors: Design, synthesis, and biological evaluation.

Journal: European journal of medicinal chemistry

Published: January 21, 2026

Discovery of enaminone-linked benzofuran derivatives as dual VEGFR-2/hCA IX inhibitors exhibiting hypoxia-mediated chemosensitization.

Discovery of enaminone-linked benzofuran derivatives as dual VEGFR-2/hCA IX inhibitors exhibiting hypoxia-mediated chemosensitization.

Journal: RSC medicinal chemistry

Published: November 21, 2025

In silico pipeline for GSK 3β inhibitor discovery in Alzheimer's disease using pharmacophore screening, docking, ADME filtering, and MD validation.

In silico pipeline for GSK 3β inhibitor discovery in Alzheimer's disease using pharmacophore screening, docking, ADME filtering, and MD validation.

Journal: Scientific reports

Published: November 19, 2025

Unlocking the Anticancer Potential of New Spirooxindoles via p53-MDM2/MDMX Dual Inhibition: In Vitro and In Silico Assessments.

Unlocking the Anticancer Potential of New Spirooxindoles via p53-MDM2/MDMX Dual Inhibition: In Vitro and In Silico Assessments.

Journal: Drug development research

Published: October 24, 2025

Showing 1-12 of 31

Last Updated: 09/26/2026