Manuel E. Than

Jena, TH 07745, Germany

Last Updated: 09/26/2026

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Found 28 publications

Systematic elucidation of neuron-astrocyte interaction in models of amyotrophic lateral sclerosis using multi-modal integrated bioinformatics workflow.

Systematic elucidation of neuron-astrocyte interaction in models of amyotrophic lateral sclerosis using multi-modal integrated bioinformatics workflow.

Journal: Nature communications

Published: July 25, 2019

Design, Synthesis, and Characterization of Macrocyclic Inhibitors of the Proprotein Convertase Furin.

Design, Synthesis, and Characterization of Macrocyclic Inhibitors of the Proprotein Convertase Furin.

Journal: ChemMedChem

Published: December 20, 2018

X-ray Structures of the Proprotein Convertase Furin Bound with Substrate Analogue Inhibitors Reveal Substrate Specificity Determinants beyond the S4 Pocket.

X-ray Structures of the Proprotein Convertase Furin Bound with Substrate Analogue Inhibitors Reveal Substrate Specificity Determinants beyond the S4 Pocket.

Journal: Biochemistry

Published: January 10, 2018

Optimization of Substrate-Analogue Furin Inhibitors.

Optimization of Substrate-Analogue Furin Inhibitors.

Journal: ChemMedChem

Published: September 25, 2017

Structural Studies Revealed Active Site Distortions of Human Furin by a Small Molecule Inhibitor.

Structural Studies Revealed Active Site Distortions of Human Furin by a Small Molecule Inhibitor.

Journal: ACS chemical biology

Published: August 08, 2017

Structural Studies Revealed Active Site Distortions of Human Furin by a Small Molecule Inhibitor.

Structural Studies Revealed Active Site Distortions of Human Furin by a Small Molecule Inhibitor.

Journal: ACS chemical biology

Published: April 13, 2017

Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism.

Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: September 21, 2016

The structure of a furin-antibody complex explains non-competitive inhibition by steric exclusion of substrate conformers.

The structure of a furin-antibody complex explains non-competitive inhibition by steric exclusion of substrate conformers.

Journal: Scientific reports

Published: May 25, 2016

Identification of inhibitors of the transmembrane protease FlaK of Methanococcus maripaludis.

Identification of inhibitors of the transmembrane protease FlaK of Methanococcus maripaludis.

Journal: MicrobiologyOpen

Published: November 12, 2015

Engineering a Constrained Peptidic Scaffold towards Potent and Selective Furin Inhibitors.

Engineering a Constrained Peptidic Scaffold towards Potent and Selective Furin Inhibitors.

Journal: Chembiochem : a European journal of chemical biology

Published: August 31, 2015

Insights into Sex Chromosome Evolution and Aging from the Genome of a Short-Lived Fish.

Insights into Sex Chromosome Evolution and Aging from the Genome of a Short-Lived Fish.

Journal: Cell

Published: June 03, 2015

Mutants of metal binding site M1 in APP E2 show metal specific differences in binding of heparin but not of sorLA.

Mutants of metal binding site M1 in APP E2 show metal specific differences in binding of heparin but not of sorLA.

Journal: Biochemistry

Published: April 04, 2015

Showing 1-12 of 28

Last Updated: 09/26/2026