Manuel Merlos

Barcelona Science Park
Barcelona, CT, Spain

Last Updated: 09/26/2026

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Found 53 publications

In vitro models for neuropathic pain phenotypic screening in brain therapeutics.

In vitro models for neuropathic pain phenotypic screening in brain therapeutics.

Journal: Pharmacological research

Published: December 20, 2023

Resilience to Pain-Related Depression in σ1 Receptor Knockout Mice Is Associated with the Reversal of Pain-Induced Brain Changes in Affect-Related Genes.

Resilience to Pain-Related Depression in σ1 Receptor Knockout Mice Is Associated with the Reversal of Pain-Induced Brain Changes in Affect-Related Genes.

Journal: ACS chemical neuroscience

Published: September 22, 2023

Discovery of WLB-89462, a New Drug-like and Highly Selective σ2 Receptor Ligand with Neuroprotective Properties.

Discovery of WLB-89462, a New Drug-like and Highly Selective σ2 Receptor Ligand with Neuroprotective Properties.

Journal: Journal of medicinal chemistry

Published: August 22, 2023

Development of a Novel σ1 Receptor Biosensor Based on Its Heterodimerization with Binding Immunoglobulin Protein in Living Cells.

Development of a Novel σ1 Receptor Biosensor Based on Its Heterodimerization with Binding Immunoglobulin Protein in Living Cells.

Journal: ACS chemical neuroscience

Published: May 16, 2023

Long-Lasting Nociplastic Pain Modulation by Repeated Administration of Sigma-1 Receptor Antagonist BD1063 in Fibromyalgia-like Mouse Models.

Long-Lasting Nociplastic Pain Modulation by Repeated Administration of Sigma-1 Receptor Antagonist BD1063 in Fibromyalgia-like Mouse Models.

Journal: International journal of molecular sciences

Published: September 10, 2022

EST79232 and EST79376, Two Novel Sigma-1 Receptor Ligands, Exert Neuroprotection on Models of Motoneuron Degeneration.

EST79232 and EST79376, Two Novel Sigma-1 Receptor Ligands, Exert Neuroprotection on Models of Motoneuron Degeneration.

Journal: International journal of molecular sciences

Published: May 16, 2022

Bispecific sigma-1 receptor antagonism and mu-opioid receptor partial agonism: WLB-73502, an analgesic with improved efficacy and safety profile compared to strong opioids.

Bispecific sigma-1 receptor antagonism and mu-opioid receptor partial agonism: WLB-73502, an analgesic with improved efficacy and safety profile compared to strong opioids.

Journal: Acta pharmaceutica Sinica. B

Published: April 13, 2022

Long-lasting reflexive and nonreflexive pain responses in two mouse models of fibromyalgia-like condition.

Long-lasting reflexive and nonreflexive pain responses in two mouse models of fibromyalgia-like condition.

Journal: Scientific reports

Published: April 04, 2022

Comprehensive Preclinical Assessment of Sensory, Functional, Motivational-Affective, and Neurochemical Outcomes in Neuropathic Pain: The Case of the Sigma-1 Receptor.

Comprehensive Preclinical Assessment of Sensory, Functional, Motivational-Affective, and Neurochemical Outcomes in Neuropathic Pain: The Case of the Sigma-1 Receptor.

Journal: ACS pharmacology & translational science

Published: January 12, 2022

Identification of Sodium Transients Through NaV1.5 Channels as Regulators of Differentiation in Immortalized Dorsal Root Ganglia Neurons.

Identification of Sodium Transients Through NaV1.5 Channels as Regulators of Differentiation in Immortalized Dorsal Root Ganglia Neurons.

Journal: Frontiers in cellular neuroscience

Published: November 16, 2021

Identification of Novel Regulators of Zalcitabine-Induced Neuropathic Pain.

Identification of Novel Regulators of Zalcitabine-Induced Neuropathic Pain.

Journal: ACS chemical neuroscience

Published: June 29, 2021

Neuroprotective Effects of Sigma 1 Receptor Ligands on Motoneuron Death after Spinal Root Injury in Mice.

Neuroprotective Effects of Sigma 1 Receptor Ligands on Motoneuron Death after Spinal Root Injury in Mice.

Journal: International journal of molecular sciences

Published: June 07, 2021

Showing 1-12 of 53

Last Updated: 09/26/2026