Marc Bigaud
Basel, BS, Switzerland
Last Updated: 09/26/2026
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Found 20 publications
Central Versus Peripheral Drug Exposure Ratio, a Key Differentiator for Siponimod Over Fingolimod?
Journal: Neurology and therapy
Published: February 10, 2023
Rationale for Use of Sphingosine-1-Phosphate Receptor Modulators in COVID-19 Patients: Overview of Scientific Evidence.
Journal: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
Published: December 01, 2022
Impact of Siponimod on Enteric and Central Nervous System Pathology in Late-Stage Experimental Autoimmune Encephalomyelitis.
Journal: International journal of molecular sciences
Published: October 10, 2022
Distribution and efficacy of ofatumumab and ocrelizumab in humanized CD20 mice following subcutaneous or intravenous administration.
Journal: Frontiers in immunology
Published: November 12, 2021
Increased Remyelination and Proregenerative Microglia Under Siponimod Therapy in Mechanistic Models.
Increased Remyelination and Proregenerative Microglia Under Siponimod Therapy in Mechanistic Models.
Journal: Neurology(R) neuroimmunology & neuroinflammation
Published: September 20, 2021
Siponimod (BAF312) penetrates, distributes, and acts in the central nervous system: Preclinical insights.
Journal: Multiple sclerosis journal - experimental, translational and clinical
Published: April 20, 2021
Discovery of Potent, Highly Selective, and In Vivo Efficacious, Allosteric MALT1 Inhibitors by Iterative Scaffold Morphing.
Journal: Journal of medicinal chemistry
Published: November 30, 2020
Optimization of the In Vivo Potency of Pyrazolopyrimidine MALT1 Protease Inhibitors by Reducing Metabolism and Increasing Potency in Whole Blood.
Journal: Journal of medicinal chemistry
Published: November 20, 2020
Pharmacological Inhibition of MALT1 Protease Leads to a Progressive IPEX-Like Pathology.
Journal: Frontiers in immunology
Published: January 17, 2020
Requirement of Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 Protease Activity for Fcγ Receptor-Induced Arthritis, but Not Fcγ Receptor-Mediated Platelet Elimination, in Mice.
Journal: Arthritis & rheumatology (Hoboken, N.J.)
Published: October 20, 2019
Malt1 Protease Deficiency in Mice Disrupts Immune Homeostasis at Environmental Barriers and Drives Systemic T Cell-Mediated Autoimmunity.
Journal: Journal of immunology (Baltimore, Md. : 1950)
Published: March 19, 2019
Blockade of CD40-CD154 pathway interactions suppresses ectopic lymphoid structures and inhibits pathology in the NOD/ShiLtJ mouse model of Sjögren's syndrome.
Journal: Annals of the rheumatic diseases
Published: June 13, 2018
Last Updated: 09/26/2026