Marc Hulsman

Amsterdam, NH, Netherlands

Last Updated: 09/26/2026

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Found 80 publications

Exome analysis of 22,319 individuals links extremely rare copy-number variants and 22q11.21 dosage to Alzheimer risk.

Exome analysis of 22,319 individuals links extremely rare copy-number variants and 22q11.21 dosage to Alzheimer risk.

Journal: American journal of human genetics

Published: April 20, 2026

Non-microglial downregulation of PLCG2 impairs synaptic function and elicits Alzheimer disease-related hallmarks.

Non-microglial downregulation of PLCG2 impairs synaptic function and elicits Alzheimer disease-related hallmarks.

Journal: bioRxiv : the preprint server for biology

Published: April 03, 2026

APOE and genetic risk variants influence Alzheimer's disease onset in carriers of an extra copy of APP, with and without Down syndrome.

APOE and genetic risk variants influence Alzheimer's disease onset in carriers of an extra copy of APP, with and without Down syndrome.

Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association

Published: March 10, 2026

Loss of PILRA promotes microglial immunometabolism to reduce amyloid pathology in cell and mouse models of Alzheimer's disease.

Loss of PILRA promotes microglial immunometabolism to reduce amyloid pathology in cell and mouse models of Alzheimer's disease.

Journal: Science translational medicine

Published: December 03, 2025

Genomic analyses reveal new insights into Alzheimer's disease.

Genomic analyses reveal new insights into Alzheimer's disease.

Journal: medRxiv : the preprint server for health sciences

Published: November 24, 2025

Genetic Modifiers of ABCA1 Activity Interact with APOE Isoforms to Mediate Alzheimer's Disease Risk.

Genetic Modifiers of ABCA1 Activity Interact with APOE Isoforms to Mediate Alzheimer's Disease Risk.

Journal: Annals of neurology

Published: October 16, 2025

Assessing the de novo paradigm in sporadic early-onset Alzheimer disease trios.

Assessing the de novo paradigm in sporadic early-onset Alzheimer disease trios.

Journal: Molecular psychiatry

Published: October 02, 2025

Soluble SORL1 in cerebrospinal fluid as a marker for functional impact of rare SORL1 variants.

Soluble SORL1 in cerebrospinal fluid as a marker for functional impact of rare SORL1 variants.

Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association

Published: September 12, 2025

Clinical Clues to the Diagnostic Yield of Genetic Testing in Adults With Late-Onset Behavioral Change.

Clinical Clues to the Diagnostic Yield of Genetic Testing in Adults With Late-Onset Behavioral Change.

Journal: Neurology. Genetics

Published: August 27, 2025

Human microglial transitions at the Aβ-tau inflection point associate with divergent pathways to dementia and resilience.

Human microglial transitions at the Aβ-tau inflection point associate with divergent pathways to dementia and resilience.

Journal: Nature medicine

Published: July 11, 2025

AD-related plasma biomarkers in centenarians: links to cognition and neuropathology.

AD-related plasma biomarkers in centenarians: links to cognition and neuropathology.

Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association

Published: July 06, 2025

Amyloid-Beta Pathology and Cognitive Performance in Centenarians.

Amyloid-Beta Pathology and Cognitive Performance in Centenarians.

Journal: JAMA neurology

Published: June 30, 2025

Showing 1-12 of 80

Last Updated: 09/26/2026