Marc Therrien
C.P. 6128, Succursale Centre Ville, H3C 3J7
Montreal, QC, Canada
Montreal, QC, Canada
Last Updated: 09/26/2026
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Found 31 publications
Targeting the H/KRAS α4-β6-α5 Allosteric Lobe with Macrocyclic Peptides.
Journal: ACS medicinal chemistry letters
Published: February 18, 2026
A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture.
Journal: bioRxiv : the preprint server for biology
Published: February 09, 2026
BRAF oncogenic mutants evade autoinhibition through a common mechanism.
Journal: Science (New York, N.Y.)
Published: May 29, 2025
Blocking a key node in cancer signalling unlocks therapeutic potential.
Journal: Nature
Published: May 07, 2025
Tao and Rap2l ensure proper Misshapen activation and levels during Drosophila border cell migration.
Tao and Rap2l ensure proper Misshapen activation and levels during Drosophila border cell migration.
Journal: Developmental cell
Published: July 21, 2023
The CNK-HYP scaffolding complex promotes RAF activation by enhancing KSR-MEK interaction.
Journal: Nature structural & molecular biology
Published: January 23, 2023
CNK2 promotes cancer cell motility by mediating ARF6 activation downstream of AXL signalling.
Journal: Nature communications
Published: October 20, 2022
Structural keys unlock RAS-MAPK cellular signalling pathway.
Journal: Nature
Published: August 15, 2022
A genetic screen in Drosophila uncovers the multifaceted properties of the NUP98-HOXA9 oncogene.
Journal: PLoS genetics
Published: March 17, 2021
ERK signalling: a master regulator of cell behaviour, life and fate.
Journal: Nature reviews. Molecular cell biology
Published: May 07, 2020
Last Updated: 09/26/2026