Marcella Manerba

Via Morego 30
Genoa, 16163, Italy

Last Updated: 09/26/2026

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Found 19 publications

The Mechanistic Understanding of RAD51 Defibrillation: A Critical Step in BRCA2-Mediated DNA Repair by Homologous Recombination.

The Mechanistic Understanding of RAD51 Defibrillation: A Critical Step in BRCA2-Mediated DNA Repair by Homologous Recombination.

Journal: International journal of molecular sciences

Published: June 17, 2022

Lactate Upregulates the Expression of DNA Repair Genes, Causing Intrinsic Resistance of Cancer Cells to Cisplatin.

Lactate Upregulates the Expression of DNA Repair Genes, Causing Intrinsic Resistance of Cancer Cells to Cisplatin.

Journal: Pathology oncology research : POR

Published: July 14, 2021

Lactate dehydrogenase inhibition affects homologous recombination repair independently of cell metabolic asset; implications for anticancer treatment.

Lactate dehydrogenase inhibition affects homologous recombination repair independently of cell metabolic asset; implications for anticancer treatment.

Journal: Biochimica et biophysica acta. General subjects

Published: June 25, 2020

Synthetic Lethality in Pancreatic Cancer: Discovery of a New RAD51-BRCA2 Small Molecule Disruptor That Inhibits Homologous Recombination and Synergizes with Olaparib.

Synthetic Lethality in Pancreatic Cancer: Discovery of a New RAD51-BRCA2 Small Molecule Disruptor That Inhibits Homologous Recombination and Synergizes with Olaparib.

Journal: Journal of medicinal chemistry

Published: February 11, 2020

Metabolic activation triggered by cAMP in MCF-7 cells generates lethal vulnerability to combined oxamate/etomoxir.

Metabolic activation triggered by cAMP in MCF-7 cells generates lethal vulnerability to combined oxamate/etomoxir.

Journal: Biochimica et biophysica acta. General subjects

Published: February 05, 2019

Rad51/BRCA2 disruptors inhibit homologous recombination and synergize with olaparib in pancreatic cancer cells.

Rad51/BRCA2 disruptors inhibit homologous recombination and synergize with olaparib in pancreatic cancer cells.

Journal: European journal of medicinal chemistry

Published: October 19, 2018

The activation of lactate dehydrogenase induced by mTOR drives neoplastic change in breast epithelial cells.

The activation of lactate dehydrogenase induced by mTOR drives neoplastic change in breast epithelial cells.

Journal: PloS one

Published: June 06, 2018

Synthetic Lethality Triggered by Combining Olaparib with BRCA2-Rad51 Disruptors.

Synthetic Lethality Triggered by Combining Olaparib with BRCA2-Rad51 Disruptors.

Journal: ACS chemical biology

Published: August 26, 2017

LDH inhibition impacts on heat shock response and induces senescence of hepatocellular carcinoma cells.

LDH inhibition impacts on heat shock response and induces senescence of hepatocellular carcinoma cells.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Published: February 16, 2017

Synthesis of natural urolithin M6, a galloflavin mimetic, as a potential inhibitor of lactate dehydrogenase A.

Synthesis of natural urolithin M6, a galloflavin mimetic, as a potential inhibitor of lactate dehydrogenase A.

Journal: Organic & biomolecular chemistry

Published: November 09, 2016

Lactate dehydrogenase inhibitors can reverse inflammation induced changes in colon cancer cells.

Lactate dehydrogenase inhibitors can reverse inflammation induced changes in colon cancer cells.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Published: July 20, 2016

Lactate dehydrogenase inhibition: exploring possible applications beyond cancer treatment.

Lactate dehydrogenase inhibition: exploring possible applications beyond cancer treatment.

Journal: Future medicinal chemistry

Published: April 08, 2016

Showing 1-12 of 19

Last Updated: 09/26/2026