Marcello Maresca

BioPharmaceuticals R&D, AstraZeneca
Goeteborg, O, Sweden

Last Updated: 09/26/2026

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Found 39 publications

Optimised genome editing for precise DNA insertion and substitution using prime editors in zebrafish.

Optimised genome editing for precise DNA insertion and substitution using prime editors in zebrafish.

Journal: eLife

Published: July 07, 2026

Single-cell and in vivo profiling reveal heterogeneous and organ-specific CRISPR-Cas9 off-target and translocation outcomes.

Single-cell and in vivo profiling reveal heterogeneous and organ-specific CRISPR-Cas9 off-target and translocation outcomes.

Journal: Nature communications

Published: April 03, 2026

Enhanced γ-globin reactivation and sickle cell correction through a repressor-to-activator motif switch in the HBG1/2 promoters.

Enhanced γ-globin reactivation and sickle cell correction through a repressor-to-activator motif switch in the HBG1/2 promoters.

Journal: Molecular therapy. Nucleic acids

Published: October 08, 2025

Aiolos and Eos drive distinct human TH17 functional states.

Aiolos and Eos drive distinct human TH17 functional states.

Journal: Cellular and molecular life sciences : CMLS

Published: August 28, 2025

A highly efficient method to differentiate CGRP-expressing peptidergic nociceptors from human induced pluripotent stem cells.

A highly efficient method to differentiate CGRP-expressing peptidergic nociceptors from human induced pluripotent stem cells.

Journal: Stem cell reports

Published: January 24, 2025

A prime editing strategy to rewrite the γ-globin promoters and reactivate fetal hemoglobin for sickle cell disease.

A prime editing strategy to rewrite the γ-globin promoters and reactivate fetal hemoglobin for sickle cell disease.

Journal: Blood

Published: January 03, 2025

Unveiling the cut-and-repair cycle of designer nucleases in human stem and T cells via CLEAR-time dPCR.

Unveiling the cut-and-repair cycle of designer nucleases in human stem and T cells via CLEAR-time dPCR.

Journal: Nature communications

Published: December 17, 2024

Prime Editing: Mechanistic Insights and DNA Repair Modulation.

Prime Editing: Mechanistic Insights and DNA Repair Modulation.

Journal: Cells

Published: December 12, 2024

Optimized prime editing of the Alzheimer's disease-associated APOE4 mutation.

Optimized prime editing of the Alzheimer's disease-associated APOE4 mutation.

Journal: Stem cell reports

Published: October 01, 2024

Dual inhibition of DNA-PK and Polϴ boosts precision of diverse prime editing systems.

Dual inhibition of DNA-PK and Polϴ boosts precision of diverse prime editing systems.

Journal: Nature communications

Published: August 21, 2024

Modified pegRNAs mitigate scaffold-derived prime editing by-products.

Modified pegRNAs mitigate scaffold-derived prime editing by-products.

Journal: Nature communications

Published: August 07, 2024

Engineered PsCas9 enables therapeutic genome editing in mouse liver with lipid nanoparticles.

Engineered PsCas9 enables therapeutic genome editing in mouse liver with lipid nanoparticles.

Journal: Nature communications

Published: February 28, 2024

Showing 1-12 of 39

Last Updated: 09/26/2026