Marco Losa

Zurich, ZH 8091, Switzerland

Last Updated: 09/26/2026

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Found 15 publications

Unraveling the Converging Roles of ASC-Dependent Inflammasomes, Interleukin-1 Superfamily Members, Serum Amyloid A, and Non-Sterile Inflammation in Disease Pathology and Fibrosis in Inflammatory Bowel Disease and Primary Sclerosing Cholangitis.

Unraveling the Converging Roles of ASC-Dependent Inflammasomes, Interleukin-1 Superfamily Members, Serum Amyloid A, and Non-Sterile Inflammation in Disease Pathology and Fibrosis in Inflammatory Bowel Disease and Primary Sclerosing Cholangitis.

Journal: International journal of molecular sciences

Published: July 16, 2025

The ASC inflammasome adapter governs SAA-derived protein aggregation in inflammatory amyloidosis.

The ASC inflammasome adapter governs SAA-derived protein aggregation in inflammatory amyloidosis.

Journal: EMBO molecular medicine

Published: May 28, 2024

Longitudinal microbiome investigation throughout prion disease course reveals pre- and symptomatic compositional perturbations linked to short-chain fatty acid metabolism and cognitive impairment in mice.

Longitudinal microbiome investigation throughout prion disease course reveals pre- and symptomatic compositional perturbations linked to short-chain fatty acid metabolism and cognitive impairment in mice.

Journal: Frontiers in microbiology

Published: April 08, 2024

Arrayed CRISPR libraries for the genome-wide activation, deletion and silencing of human protein-coding genes.

Arrayed CRISPR libraries for the genome-wide activation, deletion and silencing of human protein-coding genes.

Journal: Nature biomedical engineering

Published: September 25, 2023

An arrayed genome-wide perturbation screen identifies the ribonucleoprotein Hnrnpk as rate-limiting for prion propagation.

An arrayed genome-wide perturbation screen identifies the ribonucleoprotein Hnrnpk as rate-limiting for prion propagation.

Journal: The EMBO journal

Published: August 10, 2022

A conformational switch controlling the toxicity of the prion protein.

A conformational switch controlling the toxicity of the prion protein.

Journal: Nature structural & molecular biology

Published: December 01, 2021

Calreticulin mutations affect its chaperone function and perturb the glycoproteome.

Calreticulin mutations affect its chaperone function and perturb the glycoproteome.

Journal: Cell reports

Published: July 08, 2021

Loss of PIKfyve drives the spongiform degeneration in prion diseases.

Loss of PIKfyve drives the spongiform degeneration in prion diseases.

Journal: EMBO molecular medicine

Published: June 15, 2021

Efficacy and side effects of immune checkpoint inhibitors in the treatment of colorectal cancer.

Efficacy and side effects of immune checkpoint inhibitors in the treatment of colorectal cancer.

Journal: Therapeutic advances in gastroenterology

Published: February 10, 2021

Increased visceral sensitivity, elevated anxiety, and depression levels in patients with functional esophageal disorders and non-erosive reflux disease.

Increased visceral sensitivity, elevated anxiety, and depression levels in patients with functional esophageal disorders and non-erosive reflux disease.

Journal: Neurogastroenterology and motility

Published: November 10, 2020

Protective anti-prion antibodies in human immunoglobulin repertoires.

Protective anti-prion antibodies in human immunoglobulin repertoires.

Journal: EMBO molecular medicine

Published: May 14, 2020

An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of α-synuclein.

An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of α-synuclein.

Journal: Cell reports

Published: December 21, 2019

Showing 1-12 of 15

Last Updated: 09/26/2026