Margaret C. Frame

Edinburgh, SCT EH42XR, United Kingdom

Last Updated: 09/26/2026

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Found 67 publications

Discovery of a Highly Potent and Selective mTOR Inhibitor that Strongly Suppresses Glioblastoma Multiforme Cell Growth.

Discovery of a Highly Potent and Selective mTOR Inhibitor that Strongly Suppresses Glioblastoma Multiforme Cell Growth.

Journal: Journal of medicinal chemistry
Published: April 13, 2026

FAK modulates glioblastoma stem cell energetics via regulation of glycolysis and glutamine oxidation.

FAK modulates glioblastoma stem cell energetics via regulation of glycolysis and glutamine oxidation.

Journal: Disease models & mechanisms
Published: August 27, 2025

A comprehensive pharmacological survey across heterogeneous patient-derived glioblastoma stem cell models.

A comprehensive pharmacological survey across heterogeneous patient-derived glioblastoma stem cell models.

Journal: iScience
Published: August 20, 2025

Focal Adhesion Kinase Is Required for Intestinal Regeneration and Tumorigenesis Downstream of Wnt/c-Myc Signaling.

Focal Adhesion Kinase Is Required for Intestinal Regeneration and Tumorigenesis Downstream of Wnt/c-Myc Signaling.

Journal: Developmental cell
Published: May 11, 2025

Drug Combinations Targeting FAK and MEK Overcomes Tumor Heterogeneity in Glioblastoma.

Drug Combinations Targeting FAK and MEK Overcomes Tumor Heterogeneity in Glioblastoma.

Journal: Pharmaceutics
Published: March 06, 2025

The intrinsic substrate specificity of the human tyrosine kinome.

The intrinsic substrate specificity of the human tyrosine kinome.

Journal: Nature
Published: August 24, 2023

An ILK/STAT3 pathway controls glioblastoma stem cell plasticity.

An ILK/STAT3 pathway controls glioblastoma stem cell plasticity.

Journal: Developmental cell
Published: August 06, 2023

Quantitative proteomics identifies tumour matrisome signatures in patients with non-small cell lung cancer.

Quantitative proteomics identifies tumour matrisome signatures in patients with non-small cell lung cancer.

Journal: Frontiers in oncology
Published: March 27, 2023

Kindlin-1 regulates IL-6 secretion and modulates the immune environment in breast cancer models.

Kindlin-1 regulates IL-6 secretion and modulates the immune environment in breast cancer models.

Journal: eLife
Published: December 21, 2022

Glioblastoma and the search for non-hypothesis driven combination therapeutics in academia.

Glioblastoma and the search for non-hypothesis driven combination therapeutics in academia.

Journal: Frontiers in oncology
Published: October 20, 2022

Editor's Note: Identification of Src-Specific Phosphorylation Site on Focal Adhesion Kinase: Dissection of the Role of Src SH2 and Catalytic Functions and Their Consequences for Tumor Cell Behavior.

Editor's Note: Identification of Src-Specific Phosphorylation Site on Focal Adhesion Kinase: Dissection of the Role of Src SH2 and Catalytic Functions and Their Consequences for Tumor Cell Behavior.

Journal: Cancer research
Published: July 05, 2022

Toll-like receptor 2 orchestrates a tumor suppressor response in non-small cell lung cancer.

Toll-like receptor 2 orchestrates a tumor suppressor response in non-small cell lung cancer.

Journal: Cell reports
Published: April 12, 2022
Showing 1-12 of 67

Last Updated: 09/26/2026