Mari Takalo

Kuopio, Finland

Last Updated: 09/26/2026

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Found 38 publications

Non-microglial downregulation of PLCG2 impairs synaptic function and elicits Alzheimer disease-related hallmarks.

Non-microglial downregulation of PLCG2 impairs synaptic function and elicits Alzheimer disease-related hallmarks.

Journal: bioRxiv : the preprint server for biology
Published: April 03, 2026

Biobank-based genetic characterization of neurodegenerative diseases and idiopathic normal pressure hydrocephalus: insights and lessons learned from FinnGen.

Biobank-based genetic characterization of neurodegenerative diseases and idiopathic normal pressure hydrocephalus: insights and lessons learned from FinnGen.

Journal: Molecular psychiatry
Published: January 18, 2026

Genetic validation of ABI3 p.Ser209Phe variant and its effects on early brain pathology in asymptomatic elderly individuals.

Genetic validation of ABI3 p.Ser209Phe variant and its effects on early brain pathology in asymptomatic elderly individuals.

Journal: Alzheimer's research & therapy
Published: November 14, 2025

Lithium chloride alters Tau phosphorylation, kinase activity, and Rho GTPase signaling in cell models.

Lithium chloride alters Tau phosphorylation, kinase activity, and Rho GTPase signaling in cell models.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Published: October 31, 2025

Protective PLCG2 variants associate with a delayed onset of Alzheimer's disease among heterozygous APOE ε4 carriers.

Protective PLCG2 variants associate with a delayed onset of Alzheimer's disease among heterozygous APOE ε4 carriers.

Journal: Alzheimer's research & therapy
Published: October 07, 2025

Inflammation-induced lysosomal dysfunction in human iPSC-derived microglia is exacerbated by APOE 4/4 genotype.

Inflammation-induced lysosomal dysfunction in human iPSC-derived microglia is exacerbated by APOE 4/4 genotype.

Journal: Journal of neuroinflammation
Published: March 17, 2025

A small TAT-TrkB peptide prevents BDNF receptor cleavage and restores synaptic physiology in Alzheimer's disease.

A small TAT-TrkB peptide prevents BDNF receptor cleavage and restores synaptic physiology in Alzheimer's disease.

Journal: Molecular therapy : the journal of the American Society of Gene Therapy
Published: December 13, 2024

The protective PLCγ2-P522R variant mitigates Alzheimer's disease-associated pathologies by enhancing beneficial microglial functions.

The protective PLCγ2-P522R variant mitigates Alzheimer's disease-associated pathologies by enhancing beneficial microglial functions.

Journal: Journal of neuroinflammation
Published: November 21, 2024

C9orf72-associated and sporadic FTD patient iPSC-microglia show differences in phagocytosis and gene expression.

C9orf72-associated and sporadic FTD patient iPSC-microglia show differences in phagocytosis and gene expression.

Journal: Stem cell reports
Published: November 15, 2024

PLCG2 downregulation impairs synaptic function and increases Alzheimer's disease hallmarks in neuronal cultures.

PLCG2 downregulation impairs synaptic function and increases Alzheimer's disease hallmarks in neuronal cultures.

Journal: Nature genetics
Published: May 17, 2024

Monoallelic TYROBP deletion is a novel risk factor for Alzheimer's disease.

Monoallelic TYROBP deletion is a novel risk factor for Alzheimer's disease.

Journal: Molecular neurodegeneration
Published: May 16, 2024

Frontotemporal dementia patient-derived iPSC neurons show cell pathological hallmarks and evidence for synaptic dysfunction and DNA damage.

Frontotemporal dementia patient-derived iPSC neurons show cell pathological hallmarks and evidence for synaptic dysfunction and DNA damage.

Journal: Molecular psychiatry
Published: April 11, 2024
Showing 1-12 of 38

Last Updated: 09/26/2026