Maria B. Goncalves
London, ENG, United Kingdom
Last Updated: 09/26/2026
Save publications for later
Sign Up
Not sure about your diagnosis?
Check Your Symptoms
Found 13 publications
Treatment with KCL-286, a first-in-class retinoic acid receptor-β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease.
Journal: FEBS open bio
Published: December 15, 2025
C286, an orally available retinoic acid receptor β agonist drug, regulates multiple pathways to achieve spinal cord injury repair.
Journal: Frontiers in molecular neuroscience
Published: April 02, 2024
Phase 1 safety, tolerability, pharmacokinetics and pharmacodynamic results of KCL-286, a novel retinoic acid receptor-β agonist for treatment of spinal cord injury, in male healthy participants.
Journal: British journal of clinical pharmacology
Published: April 20, 2023
Recent advances in the design of RAR α and RAR β agonists as orally bioavailable drugs. A review.
Journal: Bioorganic & medicinal chemistry
Published: June 17, 2020
RARβ Agonist Drug (C286) Demonstrates Efficacy in a Pre-clinical Neuropathic Pain Model Restoring Multiple Pathways via DNA Repair Mechanisms.
Journal: iScience
Published: November 15, 2019
Corrigendum to "Discovery and lead optimisation of a potent, selective and orally bioavailable RARβ agonist for the potential treatment of nerve injury" [Bioorg. Med. Chem. Lett. 29(8) (2019) 995-1000].
Journal: Bioorganic & medicinal chemistry letters
Published: June 19, 2019
RARβ Agonist Drug (C286) Demonstrates Efficacy in a Pre-clinical Neuropathic Pain Model Restoring Multiple Pathways via DNA Repair Mechanisms.
Journal: iScience
Published: June 13, 2019
Discovery and lead optimisation of a potent, selective and orally bioavailable RARβ agonist for the potential treatment of nerve injury.
Journal: Bioorganic & medicinal chemistry letters
Published: January 03, 2019
Regulation of Myelination by Exosome Associated Retinoic Acid Release from NG2-Positive Cells.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience
Published: November 15, 2018
Design and synthesis of a potent, highly selective, orally bioavailable, retinoic acid receptor alpha agonist.
Journal: Bioorganic & medicinal chemistry
Published: September 28, 2017
Retinoic acid synthesis by NG2 expressing cells promotes a permissive environment for axonal outgrowth.
Journal: Neurobiology of disease
Published: July 24, 2017
Neuronal RARβ Signaling Modulates PTEN Activity Directly in Neurons and via Exosome Transfer in Astrocytes to Prevent Glial Scar Formation and Induce Spinal Cord Regeneration.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience
Published: November 27, 2015
Last Updated: 09/26/2026