Marianne C. De Villiers

Stellenbosch, WC, South Africa

Last Updated: 09/26/2026

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Found 12 publications

Inhibition of Plasmodium falciparum Hsp70-Hop partnership by 2-phenylthynesulfonamide.

Inhibition of Plasmodium falciparum Hsp70-Hop partnership by 2-phenylthynesulfonamide.

Journal: Frontiers in molecular biosciences

Published: May 18, 2022

Adsorption to the Surface of Hemozoin Crystals: Structure-Based Design and Synthesis of Amino-Phenoxazine β-Hematin Inhibitors.

Adsorption to the Surface of Hemozoin Crystals: Structure-Based Design and Synthesis of Amino-Phenoxazine β-Hematin Inhibitors.

Journal: ChemMedChem

Published: March 16, 2022

Inhibitors of the Plasmodium falciparum Hsp90 towards Selective Antimalarial Drug Design: The Past, Present and Future.

Inhibitors of the Plasmodium falciparum Hsp90 towards Selective Antimalarial Drug Design: The Past, Present and Future.

Journal: Cells

Published: September 23, 2021

Toward a Stable and Potent Coenzyme A-Targeting Antiplasmodial Agent: Structure-Activity Relationship Studies of N-Phenethyl-α-methyl-pantothenamide.

Toward a Stable and Potent Coenzyme A-Targeting Antiplasmodial Agent: Structure-Activity Relationship Studies of N-Phenethyl-α-methyl-pantothenamide.

Journal: ACS infectious diseases

Published: May 08, 2020

The changing landscape of infective endocarditis in South Africa.

The changing landscape of infective endocarditis in South Africa.

Journal: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde

Published: July 26, 2019

Acetyl-4'-phosphopantetheine is stable in serum and prevents phenotypes induced by pantothenate kinase deficiency.

Acetyl-4'-phosphopantetheine is stable in serum and prevents phenotypes induced by pantothenate kinase deficiency.

Journal: Scientific reports

Published: June 01, 2017

Antiplasmodial Mode of Action of Pantothenamides: Pantothenate Kinase Serves as a Metabolic Activator Not as a Target.

Antiplasmodial Mode of Action of Pantothenamides: Pantothenate Kinase Serves as a Metabolic Activator Not as a Target.

Journal: ACS infectious diseases

Published: April 25, 2017

Metabolism: Jump-starting CoA biosynthesis.

Metabolism: Jump-starting CoA biosynthesis.

Journal: Nature chemical biology

Published: September 18, 2015

A pantetheinase-resistant pantothenamide with potent, on-target, and selective antiplasmodial activity.

A pantetheinase-resistant pantothenamide with potent, on-target, and selective antiplasmodial activity.

Journal: Antimicrobial agents and chemotherapy

Published: December 09, 2014

Recent advances in targeting coenzyme A biosynthesis and utilization for antimicrobial drug development.

Recent advances in targeting coenzyme A biosynthesis and utilization for antimicrobial drug development.

Journal: Biochemical Society transactions

Published: August 12, 2014

Variation in pantothenate kinase type determines the pantothenamide mode of action and impacts on coenzyme A salvage biosynthesis.

Variation in pantothenate kinase type determines the pantothenamide mode of action and impacts on coenzyme A salvage biosynthesis.

Journal: The FEBS journal

Published: May 30, 2014

Structural modification of pantothenamides counteracts degradation by pantetheinase and improves antiplasmodial activity.

Structural modification of pantothenamides counteracts degradation by pantetheinase and improves antiplasmodial activity.

Journal: ACS medicinal chemistry letters

Published: May 13, 2013

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Last Updated: 09/26/2026