Marie-christine Caron

Quebec, QC, Canada

Last Updated: 09/26/2026

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Found 25 publications

Pathogenic variants in MAEA disrupt DNA replication fork stability and are associated with developmental abnormalities in humans.

Pathogenic variants in MAEA disrupt DNA replication fork stability and are associated with developmental abnormalities in humans.

Journal: Science advances
Published: August 29, 2025

Polθ activity modulates sensitivity to standard therapies in DNMT3A-deficient leukemia.

Polθ activity modulates sensitivity to standard therapies in DNMT3A-deficient leukemia.

Journal: Cell reports. Medicine
Published: October 22, 2024

DNA polymerase theta-mediated DNA repair is a functional dependency and therapeutic vulnerability in DNMT3A deficient leukemia cells.

DNA polymerase theta-mediated DNA repair is a functional dependency and therapeutic vulnerability in DNMT3A deficient leukemia cells.

Journal: bioRxiv : the preprint server for biology
Published: October 16, 2024

PNKP safeguards stalled replication forks from nuclease-dependent degradation during replication stress.

PNKP safeguards stalled replication forks from nuclease-dependent degradation during replication stress.

Journal: Cell reports
Published: March 26, 2024

Cell-type-specific CAG repeat expansions and toxicity of mutant Huntingtin in human striatum and cerebellum.

Cell-type-specific CAG repeat expansions and toxicity of mutant Huntingtin in human striatum and cerebellum.

Journal: Nature genetics
Published: June 21, 2023

Cell Type Specific CAG Repeat Expansions and Toxicity of Mutant Huntingtin in Human Striatum and Cerebellum.

Cell Type Specific CAG Repeat Expansions and Toxicity of Mutant Huntingtin in Human Striatum and Cerebellum.

Journal: bioRxiv : the preprint server for biology
Published: June 19, 2023

ZNF432 stimulates PARylation and inhibits DNA resection to balance PARPi sensitivity and resistance.

ZNF432 stimulates PARylation and inhibits DNA resection to balance PARPi sensitivity and resistance.

Journal: Nucleic acids research
Published: December 13, 2022

DNA polymerase θ protects leukemia cells from metabolically induced DNA damage.

DNA polymerase θ protects leukemia cells from metabolically induced DNA damage.

Journal: Blood
Published: September 15, 2022

FANCD2 and RAD51 recombinase directly inhibit DNA2 nuclease at stalled replication forks and FANCD2 acts as a novel RAD51 mediator in strand exchange to promote genome stability.

FANCD2 and RAD51 recombinase directly inhibit DNA2 nuclease at stalled replication forks and FANCD2 acts as a novel RAD51 mediator in strand exchange to promote genome stability.

Journal: Nucleic acids research
Published: September 12, 2022

Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability.

Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability.

Journal: Cell
Published: June 30, 2022

XAB2 promotes Ku eviction from single-ended DNA double-strand breaks independently of the ATM kinase.

XAB2 promotes Ku eviction from single-ended DNA double-strand breaks independently of the ATM kinase.

Journal: Nucleic acids research
Published: May 21, 2021

FAN1 exo- not endo-nuclease pausing on disease-associated slipped-DNA repeats: A mechanism of repeat instability.

FAN1 exo- not endo-nuclease pausing on disease-associated slipped-DNA repeats: A mechanism of repeat instability.

Journal: Cell reports
Published: May 06, 2021
Showing 1-12 of 25

Last Updated: 09/26/2026