Marina Demetriades

Oxford, ENG OX13TA, United Kingdom

Last Updated: 09/26/2026

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Found 15 publications

Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors.

Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors.

Journal: Journal of medicinal chemistry

Published: November 11, 2021

Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models.

Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models.

Journal: Science translational medicine

Published: March 04, 2016

Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain.

Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain.

Journal: PloS one

Published: April 02, 2015

Pharmacological inhibition of FTO.

Pharmacological inhibition of FTO.

Journal: PloS one

Published: October 10, 2014

Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation.

Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation.

Journal: The Journal of biological chemistry

Published: April 30, 2014

Structure of human RNA N⁶-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation.

Structure of human RNA N⁶-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation.

Journal: Nucleic acids research

Published: February 04, 2014

On the histone lysine methyltransferase activity of fungal metabolite chaetocin.

On the histone lysine methyltransferase activity of fungal metabolite chaetocin.

Journal: Journal of medicinal chemistry

Published: October 09, 2013

Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2.

Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2.

Journal: The Journal of physiology

Published: May 22, 2013

Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.

Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.

Journal: ACS chemical biology

Published: May 21, 2013

Structural basis for inhibition of the fat mass and obesity associated protein (FTO).

Structural basis for inhibition of the fat mass and obesity associated protein (FTO).

Journal: Journal of medicinal chemistry

Published: April 04, 2013

Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway.

Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway.

Journal: Acta crystallographica. Section D, Biological crystallography

Published: February 22, 2013

Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors.

Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors.

Journal: Journal of medicinal chemistry

Published: December 14, 2012

Showing 1-12 of 15

Last Updated: 09/26/2026