Mark A. Birrell

Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca
London, ENG SW72AZ, United Kingdom

Last Updated: 09/26/2026

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Found 56 publications

TRPV4: A Promising Therapeutic Target Ion Channel─Discovery of Ultrapotent Selective Antagonists.

TRPV4: A Promising Therapeutic Target Ion Channel─Discovery of Ultrapotent Selective Antagonists.

Journal: Journal of medicinal chemistry

Published: July 11, 2026

PI3Kγδ inhibition suppresses key disease features in a rat model of asthma.

PI3Kγδ inhibition suppresses key disease features in a rat model of asthma.

Journal: Respiratory research

Published: January 05, 2024

Characterization of Selective and Potent JAK1 Inhibitors Intended for the Inhaled Treatment of Asthma.

Characterization of Selective and Potent JAK1 Inhibitors Intended for the Inhaled Treatment of Asthma.

Journal: Drug design, development and therapy

Published: December 22, 2021

Aprepitant for Cough in Lung Cancer. A Randomized Placebo-controlled Trial and Mechanistic Insights.

Aprepitant for Cough in Lung Cancer. A Randomized Placebo-controlled Trial and Mechanistic Insights.

Journal: American journal of respiratory and critical care medicine

Published: September 23, 2020

Back to the future: re-establishing guinea pig in vivo asthma models.

Back to the future: re-establishing guinea pig in vivo asthma models.

Journal: Clinical science (London, England : 1979)

Published: April 03, 2020

"Truth is ever to be found in simplicity, and not in the multiplicity and confusion of things" - Sir Isaac Newton.

"Truth is ever to be found in simplicity, and not in the multiplicity and confusion of things" - Sir Isaac Newton.

Journal: The European respiratory journal

Published: August 06, 2019

Novel airway smooth muscle-mast cell interactions and a role for the TRPV4-ATP axis in non-atopic asthma.

Novel airway smooth muscle-mast cell interactions and a role for the TRPV4-ATP axis in non-atopic asthma.

Journal: The European respiratory journal

Published: July 22, 2019

Protein Phosphatase 2A Reduces Cigarette Smoke-induced Cathepsin S and Loss of Lung Function.

Protein Phosphatase 2A Reduces Cigarette Smoke-induced Cathepsin S and Loss of Lung Function.

Journal: American journal of respiratory and critical care medicine

Published: January 15, 2019

Modelling the asthma phenotype: impact of cigarette smoke exposure.

Modelling the asthma phenotype: impact of cigarette smoke exposure.

Journal: Respiratory research

Published: December 12, 2017

Response to 'Effects of diesel exhaust particles on coagulation'.

Response to 'Effects of diesel exhaust particles on coagulation'.

Journal: British journal of pharmacology

Published: September 05, 2017

Downregulation of MicroRNA-126 Augments DNA Damage Response in Cigarette Smokers and Patients with Chronic Obstructive Pulmonary Disease.

Downregulation of MicroRNA-126 Augments DNA Damage Response in Cigarette Smokers and Patients with Chronic Obstructive Pulmonary Disease.

Journal: American journal of respiratory and critical care medicine

Published: July 29, 2017

XEN-D0501, a Novel Transient Receptor Potential Vanilloid 1 Antagonist, Does Not Reduce Cough in Patients with Refractory Cough.

XEN-D0501, a Novel Transient Receptor Potential Vanilloid 1 Antagonist, Does Not Reduce Cough in Patients with Refractory Cough.

Journal: American journal of respiratory and critical care medicine

Published: June 27, 2017

Showing 1-12 of 56

Last Updated: 09/26/2026