Mark J. Fiers

Leuven, VLG 3000, Belgium

Last Updated: 09/26/2026

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Found 45 publications

Phagocytes as plaque catalysts: Human macrophages generate seeding-competent Aβ42 fibrils with cross-seeding activity.

Phagocytes as plaque catalysts: Human macrophages generate seeding-competent Aβ42 fibrils with cross-seeding activity.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: March 02, 2026

Phagocytes as Plaque Catalysts: Human Macrophages Actively Generate Pathogenic Aβ42 Fibrils with Seeding and Cross-Seeding Potency.

Phagocytes as Plaque Catalysts: Human Macrophages Actively Generate Pathogenic Aβ42 Fibrils with Seeding and Cross-Seeding Potency.

Journal: bioRxiv : the preprint server for biology

Published: November 24, 2025

Human microglial transitions at the Aβ-tau inflection point associate with divergent pathways to dementia and resilience.

Human microglial transitions at the Aβ-tau inflection point associate with divergent pathways to dementia and resilience.

Journal: Nature medicine

Published: July 11, 2025

The Alzheimer's therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia.

The Alzheimer's therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia.

Journal: Nature neuroscience

Published: July 30, 2024

Deep proteomic analysis of microglia reveals fundamental biological differences between model systems.

Deep proteomic analysis of microglia reveals fundamental biological differences between model systems.

Journal: Cell reports

Published: May 16, 2024

NACC2, a molecular effector of miR-132 regulation at the interface between adult neurogenesis and Alzheimer's disease.

NACC2, a molecular effector of miR-132 regulation at the interface between adult neurogenesis and Alzheimer's disease.

Journal: Scientific reports

Published: May 03, 2024

APOE from astrocytes restores Alzheimer's Aβ-pathology and DAM-like responses in APOE deficient microglia.

APOE from astrocytes restores Alzheimer's Aβ-pathology and DAM-like responses in APOE deficient microglia.

Journal: EMBO molecular medicine

Published: April 24, 2024

Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer's disease.

Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer's disease.

Journal: Molecular neurodegeneration

Published: November 24, 2023

MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer's disease.

MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer's disease.

Journal: Science (New York, N.Y.)

Published: September 14, 2023

Microglia-astrocyte crosstalk in the amyloid plaque niche of an Alzheimer's disease mouse model, as revealed by spatial transcriptomics.

Microglia-astrocyte crosstalk in the amyloid plaque niche of an Alzheimer's disease mouse model, as revealed by spatial transcriptomics.

Journal: Cell reports

Published: June 20, 2023

The γ-secretase substrate proteome and its role in cell signaling regulation.

The γ-secretase substrate proteome and its role in cell signaling regulation.

Journal: Molecular cell

Published: February 02, 2023

microRNA-132 regulates gene expression programs involved in microglial homeostasis.

microRNA-132 regulates gene expression programs involved in microglial homeostasis.

Journal: iScience

Published: December 22, 2022

Showing 1-12 of 45

Last Updated: 09/26/2026