Mark J. Wigglesworth

AstraZeneca R&D
Moelndal, O 43150, Sweden

Last Updated: 09/26/2026

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Found 26 publications

Multiplexed Guide RNA Expression Leads to Increased Mutation Frequency in Targeted Window Using a CRISPR-Guided Error-Prone DNA Polymerase in Saccharomyces cerevisiae.

Multiplexed Guide RNA Expression Leads to Increased Mutation Frequency in Targeted Window Using a CRISPR-Guided Error-Prone DNA Polymerase in Saccharomyces cerevisiae.

Journal: ACS synthetic biology

Published: July 24, 2023

RT-PCR genotyping assays to identify SARS-CoV-2 variants in England in 2021: a design and retrospective evaluation study.

RT-PCR genotyping assays to identify SARS-CoV-2 variants in England in 2021: a design and retrospective evaluation study.

Journal: The Lancet. Microbe

Published: November 24, 2022

Genetically Encoded Whole Cell Biosensor for Drug Discovery of HIF-1 Interaction Inhibitors.

Genetically Encoded Whole Cell Biosensor for Drug Discovery of HIF-1 Interaction Inhibitors.

Journal: ACS synthetic biology

Published: October 12, 2022

Determining the Effects of Differential Expression of GRKs and β-arrestins on CLR-RAMP Agonist Bias.

Determining the Effects of Differential Expression of GRKs and β-arrestins on CLR-RAMP Agonist Bias.

Journal: Frontiers in physiology

Published: December 21, 2021

High throughput diagnostics and dynamic risk assessment of SARS-CoV-2 variants of concern.

High throughput diagnostics and dynamic risk assessment of SARS-CoV-2 variants of concern.

Journal: EBioMedicine

Published: April 16, 2021

A Perspective on Synthetic Biology in Drug Discovery and Development-Current Impact and Future Opportunities.

A Perspective on Synthetic Biology in Drug Discovery and Development-Current Impact and Future Opportunities.

Journal: SLAS discovery : advancing life sciences R & D

Published: April 09, 2021

CGRP, adrenomedullin and adrenomedullin 2 display endogenous GPCR agonist bias in primary human cardiovascular cells.

CGRP, adrenomedullin and adrenomedullin 2 display endogenous GPCR agonist bias in primary human cardiovascular cells.

Journal: Communications biology

Published: March 11, 2021

Hit Discovery Methodology.

Hit Discovery Methodology.

Journal: SLAS discovery : advancing life sciences R & D

Published: January 22, 2021

Evaluation of the Use of Cold Plasma for Microtiter Plate Cleaning to Reduce Plastic Biohazard Waste.

Evaluation of the Use of Cold Plasma for Microtiter Plate Cleaning to Reduce Plastic Biohazard Waste.

Journal: SLAS technology

Published: November 30, 2020

A High-Throughput Cellular Screening Assay for Small-Molecule Inhibitors and Activators of Cytoplasmic Dynein-1-Based Cargo Transport.

A High-Throughput Cellular Screening Assay for Small-Molecule Inhibitors and Activators of Cytoplasmic Dynein-1-Based Cargo Transport.

Journal: SLAS discovery : advancing life sciences R & D

Published: May 22, 2020

Receptor component protein, an endogenous allosteric modulator of family B G protein coupled receptors.

Receptor component protein, an endogenous allosteric modulator of family B G protein coupled receptors.

Journal: Biochimica et biophysica acta. Biomembranes

Published: September 09, 2019

Development of a High-Throughput Cytometric Screen to Identify Anti- Wolbachia Compounds: The Power of Public-Private Partnership.

Development of a High-Throughput Cytometric Screen to Identify Anti- Wolbachia Compounds: The Power of Public-Private Partnership.

Journal: SLAS discovery : advancing life sciences R & D

Published: April 09, 2019

Showing 1-12 of 26

Last Updated: 09/26/2026