Mark J. Murphy

Allschwil, BL, Switzerland

Last Updated: 09/26/2026

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Found 12 publications

Efficacy of IDOR-1117-2520, a novel, orally available CCR6 antagonist in preclinical models of skin dermatitis.

Efficacy of IDOR-1117-2520, a novel, orally available CCR6 antagonist in preclinical models of skin dermatitis.

Journal: British journal of pharmacology

Published: October 18, 2024

Pharmacodynamics of the S1P1 receptor modulator cenerimod in a phase 2b randomised clinical trial in patients with moderate to severe SLE.

Pharmacodynamics of the S1P1 receptor modulator cenerimod in a phase 2b randomised clinical trial in patients with moderate to severe SLE.

Journal: Annals of the rheumatic diseases

Published: August 14, 2024

Discovery of the Clinical Candidate IDOR-1117-2520: A Potent and Selective Antagonist of CCR6 for Autoimmune Diseases.

Discovery of the Clinical Candidate IDOR-1117-2520: A Potent and Selective Antagonist of CCR6 for Autoimmune Diseases.

Journal: Journal of medicinal chemistry

Published: May 10, 2024

Discovery and Characterization of a New Class of C5aR1 Antagonists Showing In Vivo Activity.

Discovery and Characterization of a New Class of C5aR1 Antagonists Showing In Vivo Activity.

Journal: Journal of medicinal chemistry

Published: March 14, 2024

Cenerimod, a sphingosine-1-phosphate receptor modulator, versus placebo in patients with moderate-to-severe systemic lupus erythematosus (CARE): an international, double-blind, randomised, placebo-controlled, phase 2 trial.

Cenerimod, a sphingosine-1-phosphate receptor modulator, versus placebo in patients with moderate-to-severe systemic lupus erythematosus (CARE): an international, double-blind, randomised, placebo-controlled, phase 2 trial.

Journal: The Lancet. Rheumatology

Published: February 12, 2024

The membrane attack complex drives thrombotic microangiopathy in complement mediated atypical hemolytic uremic syndrome.

The membrane attack complex drives thrombotic microangiopathy in complement mediated atypical hemolytic uremic syndrome.

Journal: Kidney international

Published: December 05, 2023

Discovery of Clinical Candidate ACT-777991, a Potent CXCR3 Antagonist for Antigen-Driven and Inflammatory Pathologies.

Discovery of Clinical Candidate ACT-777991, a Potent CXCR3 Antagonist for Antigen-Driven and Inflammatory Pathologies.

Journal: Journal of medicinal chemistry

Published: March 08, 2023

In Vitro Characterization of Sphingosine 1-Phosphate Receptor 1 (S1P1) Expression and Mediated Migration of Primary Human T and B Cells in the Context of Cenerimod, a Novel, Selective S1P1 Receptor Modulator.

In Vitro Characterization of Sphingosine 1-Phosphate Receptor 1 (S1P1) Expression and Mediated Migration of Primary Human T and B Cells in the Context of Cenerimod, a Novel, Selective S1P1 Receptor Modulator.

Journal: International journal of molecular sciences

Published: November 29, 2021

Cenerimod, a selective S1P1 receptor modulator, improves organ-specific disease outcomes in animal models of Sjögren's syndrome.

Cenerimod, a selective S1P1 receptor modulator, improves organ-specific disease outcomes in animal models of Sjögren's syndrome.

Journal: Arthritis research & therapy

Published: March 03, 2021

The potency of selatogrel, a reversible antagonist of the P2Y12 receptor, is affected by calcium concentration.

The potency of selatogrel, a reversible antagonist of the P2Y12 receptor, is affected by calcium concentration.

Journal: Platelets

Published: January 11, 2021

Preclinical to clinical translation of cenerimod, a novel S1P1 receptor modulator, in systemic lupus erythematosus.

Preclinical to clinical translation of cenerimod, a novel S1P1 receptor modulator, in systemic lupus erythematosus.

Journal: RMD open

Published: April 06, 2020

ATP-induced cellular stress and mitochondrial toxicity in cells expressing purinergic P2X7 receptor.

ATP-induced cellular stress and mitochondrial toxicity in cells expressing purinergic P2X7 receptor.

Journal: Pharmacology research & perspectives

Published: October 08, 2014

Showing 1-12 of 12

Last Updated: 09/26/2026