Last Updated: 09/26/2026
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Found 102 publications
Polymerized Z-α-1 antitrypsin leads to lung injury in a murine model of emphysema.
Journal: JCI insight
Published: August 11, 2026
Alpha-defensins promote macrophage inflammatory activation via RNF31 signaling.
Journal: Genes & genomics
Published: December 10, 2025
Multi-Society Expert Panel Consensus Guidance Regarding Clinical Assessment and Clinical Trial Endpoints in Adults With Alpha-1 Antitrypsin Deficiency-Associated Liver Disease.
Journal: Gastroenterology
Published: October 08, 2025
Pioglitazone reduces hepatic α-1 antitrypsin accumulation through autophagy and AMPK activation in α-1 antitrypsin-deficient mice.
Journal: American journal of physiology. Gastrointestinal and liver physiology
Published: September 29, 2025
Alpha-defensins increase NTHi binding but not engulfment by the macrophages enhancing airway inflammation in Alpha-1 antitrypsin deficiency.
Journal: Frontiers in immunology
Published: December 11, 2024
Extracellular Vesicle-Associated Neutrophil Elastase Activates Hepatic Stellate Cells and Promotes Liver Fibrogenesis via ERK1/2 Pathway.
Journal: bioRxiv : the preprint server for biology
Published: September 04, 2024
Plasma Extracellular Vesicle-derived MicroRNA Associated with Human Alpha-1 Antitrypsin Deficiency-mediated Liver Disease.
Journal: Journal of clinical and translational hepatology
Published: July 25, 2024
Liver Characterization of a Cohort of Alpha-1 Antitrypsin Deficiency Patients with and without Lung Disease.
Journal: Journal of clinical and translational hepatology
Published: June 17, 2024
Recombinant Alpha-1 Antitrypsin-Fc Fusion Protein INBRX-101 in Adults With Alpha-1 Antitrypsin Deficiency: A Phase 1 Study.
Journal: Chronic obstructive pulmonary diseases (Miami, Fla.)
Published: May 29, 2024
Inhaled alpha-1 antitrypsin (AAT) restores lower respiratory tract protease-antiprotease homoeostasis and reduces inflammation in AAT-deficient individuals: a randomised phase 2 study.
Journal: ERJ open research
Published: May 25, 2024
Last Updated: 09/26/2026