Mark R. Holt

St Thomas' Hospital
London, ENG SE17EH, United Kingdom

Last Updated: 09/26/2026

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Found 28 publications

Targeting PKGIα Cys42 attenuates cardiac dysfunction in heart failure with preserved ejection fraction.

Targeting PKGIα Cys42 attenuates cardiac dysfunction in heart failure with preserved ejection fraction.

Journal: Science advances

Published: August 19, 2026

Location-Dependent Differences in Cardiac and Skeletal Muscle Dysfunction Associated With Truncating Titin (ttn.2) Variants.

Location-Dependent Differences in Cardiac and Skeletal Muscle Dysfunction Associated With Truncating Titin (ttn.2) Variants.

Journal: Circulation research

Published: January 07, 2026

POU4F2/Brn-3b is Essential for Spermatogenesis and its Disruption is Linked to Male Infertility in Mice and Humans.

POU4F2/Brn-3b is Essential for Spermatogenesis and its Disruption is Linked to Male Infertility in Mice and Humans.

Journal: Research square

Published: November 24, 2025

A comprehensive framework for the interpretation of TTN missense variants.

A comprehensive framework for the interpretation of TTN missense variants.

Journal: Genome medicine

Published: July 17, 2025

Bystanders' attitudes towards drone delivered Automated External Defibrillators for out-of-hospital cardiac arrest: A qualitative interview study.

Bystanders' attitudes towards drone delivered Automated External Defibrillators for out-of-hospital cardiac arrest: A qualitative interview study.

Journal: PloS one

Published: July 11, 2025

The use of drone-delivered Automated External Defibrillators in the emergency response for out-of-hospital cardiac arrest. A simulation study.

The use of drone-delivered Automated External Defibrillators in the emergency response for out-of-hospital cardiac arrest. A simulation study.

Journal: Resuscitation plus

Published: June 12, 2025

Desmin disorganisation: A key feature in feline hypertrophic cardiomyopathy.

Desmin disorganisation: A key feature in feline hypertrophic cardiomyopathy.

Journal: PloS one

Published: April 04, 2025

Sos1 ablation alters focal adhesion dynamics and increases Mmp2/9-dependent gelatinase activity in primary mouse embryonic fibroblasts.

Sos1 ablation alters focal adhesion dynamics and increases Mmp2/9-dependent gelatinase activity in primary mouse embryonic fibroblasts.

Journal: Cell communication and signaling : CCS

Published: October 24, 2024

Missense mutations in the central domains of cardiac myosin binding protein-C and their potential contribution to hypertrophic cardiomyopathy.

Missense mutations in the central domains of cardiac myosin binding protein-C and their potential contribution to hypertrophic cardiomyopathy.

Journal: The Journal of biological chemistry

Published: June 01, 2023

AMPK is a mechano-metabolic sensor linking cell adhesion and mitochondrial dynamics to Myosin-dependent cell migration.

AMPK is a mechano-metabolic sensor linking cell adhesion and mitochondrial dynamics to Myosin-dependent cell migration.

Journal: Nature communications

Published: May 13, 2022

Electrical stimulation applied during differentiation drives the hiPSC-CMs towards a mature cardiac conduction-like cells.

Electrical stimulation applied during differentiation drives the hiPSC-CMs towards a mature cardiac conduction-like cells.

Journal: Biochemical and biophysical research communications

Published: August 04, 2020

Making sense of missense variants in TTN-related congenital myopathies.

Making sense of missense variants in TTN-related congenital myopathies.

Journal: Acta neuropathologica

Published: May 19, 2020

Showing 1-12 of 28

Last Updated: 09/26/2026